Biosciences Publications, Presentations, Abstracts, and Patents

Jump to: Biophysics | Cancer Biology |Medicinal Chemistry | Neuroscience | Pharmaceutical Sciences |Physiology | Toxicology| Other | Patents

Biophysics

Publications

Chang, P.Y., R. Doppalapudi, J. Bakke, A. Puey, and S. Lin. Evaluation of the biological effectiveness of shielding material in transgenic animals. Radiat Environ Biophysics e-publication: http://www.springerlink.com/content/1432-2099/?k=chang (2006).

Abstracts and Presentations

Blakely, E.A., A.C. Thompson, P. Chang, R.I. Schwarz, K. Bjornstad, C. Rosen, C. Wisnerski, and D. Mocherla. Low LET bystander effects in cells in vitro are significantly less than published for high LET radiation. DOE Low Dose Workshop, Washington, D.C., Aug 1–5, 2006.

Blakely, E.A., A.C. Thompson, R.I. Schwarz, P. Chang, K. Bjornstad, C. Rosen, C. Wisnewski, D. Mocherla, and B. Parvin. Radiation-induced bystander effects with a 12.5 kev X-ray microbeam. 7th International Workshop on Microbeam Probes of Cellular Radiation Response, Columbia University, New York, NY, March 15–17, 2006.

Blakely, E.A., P.Y. Chang, K.A. Bjornstad, M. Dosanjh, C. Cherbonnel, and C. Rosen. Particle radiation signals the expression of genes in stress-associated pathways. Committee on Space Research (COSPAR) Scientific Assembly, Beijing, China, July 16–23, 2006.

Chang, P.Y., K.A. Bjornstad, C.J. Rosen, and E.A. Blakely. Particle-radiation induced gene expression in differentiating human lens epithelial cells. 4th International Workshop on Space Radiation Research, Moscow/St. Petersburg, Russia, June 5–9, 2006.

Cancer Biology

Publications

Laderoute, K., K. Amin, J. Calaoagan, M. Knapp, J. Orduna, T. Le, and C. Viollet. 5′-AMP activated protein kinase-a (AMPKa) is induced by low oxygen and glucose deprivation conditions found in solid tumor microenvironments. Mol Cell Biol 26:5336-47 (2006).

Abstracts and Presentations

Amin, K., B.G. Sato, Z.A. Haroon, and B.J. Murphy. MTF-1 contributes to the activation of MMP-2. Experimental Biology (FASEB) Meeting, San Francisco, CA, April 2–4, 2006.

Dixit, S., T. Le, K. Amin, C. Comstock, and G.W. Faris. Differential optical mammography. Network for Translational Research: Optical Imaging (NTROI) Breast Cancer Imaging Network Retreat/Workshop, Newport Beach, CA, June 22–24, 2006.

Hobbs, P., W.-R. Chao, K. Amin, C. Green, T. Le, H. Parish, T. Parman, B. Sato, M. Tanga, D. Yean, and M. Tanabe. SR16388 inhibits non-small cell lung tumor growth and angiogenesis. American Association for Cancer Research (AACR) 97th Annual Meeting, Washington, DC, April 1–4, 2006.

Medicinal Chemistry

Publications

Anderson, M.O., J. Sherrill, P.B. Madrid, A.P. Liou, J.L. Weisman, J.L. DeRisi, and R.K. Guy. Parallel synthesis of 9-aminoacridines and their evaluation against chloroquinine-resistant Plasmodium falciparum. Bioorg Med Chem 14:334–343 (2006).

Barnaby, C.H.M., J. Witkop, J. Sherrill, M.O. Anderson, P.B. Madrid, J.A. Zorn, S.B. Prusiner, F.E. Cohen, and R.K. Guy. Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells. Bioorg Med Chem 16:4913–4916 (2006).

Brill, S.S., A.M. Furnisky, M.N. Ho, M.J. Furniss, Y. Li, A.G. Green, W.W. Bradford, C.E. Green, I.M. Kapetanovic, and L.V. Iyer. Glucuronidation of trans-resveratrol by human liver and intestinal microsomes and UGT isoforms. J Pharm Pharmacol 58:469–479 (2006).

Knize, M.G., F.T. Hatch, M.J. Tanga, E.V. Lau, and M.E. Colvin. A QSAR for the mutagenic potencies of twelve 2-amino-trimethylimida zopyridine isomers: Structural, quantum chemical, and hydropathic factors. Environ Mol Mutagen 47:132–146 (2006).

Abstracts and Presentations

Rhee, S., M. Tanga, Y.-H. Chung, and J.S. Park. Carbon-14 labelling of DW-116, a quinolone antibiotic drug. 9th International Symposium on the Synthesis and Applications of Isotopically Labelled Compounds, Edinburgh, Scotland, July 16–20, 2006.

Wang, J., C. Yang, E. Wang, N. Zaveri, and P. Liu. Stability-indicating HPLC assay and decomposition product characterization of compound SR16157 (NSC 732011). Symposium Drug Analysis 2006, Namur, Belgium, May 16–19, 2006.

Wolter, M.A., G.S. Choy, A. Rosowsky, W.-R. Chao, M. Ramirez, G. Berk. Combining Talotrexin (PT-523) with cytotoxic agents in CEM cell cultures and A549 non-small cell lung cancer athymic nude mice xenografts. 18th European Organisation for Research and Treatment of Cancer-National Cancer Institute-American Association for Cancer Research (EORTC-NCI-AACR) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, November 7–10, 2006.

Neuroscience

Publications

He, H., H.-T. Cho, W. Li, T. Kawakita, L. Jong, C. Scheffer, and G. Tseng. Signaling transduction pathways required for ex vivo expansion of human limbal explants on intact amniotic membrane. Invest Ophthalmol Vis Sci 47:151–157 (2006).

Lu, J., and M.A. Greco. Sleep circuitry and the hypnotic mechanism of GABAA Drugs. J Clin Sleep Med Suppl 2(2):819–826 (2006).

Quik, M., L. Chen, N. Parameswaran, X.M. Xie, J.W. Langston, and S.E. McCallum. Chronic oral nicotine normalizes dopaminergic function and synaptic plasticity in MPTP-lesioned primates. J Neurosci 26:4681–4689 (2006).

Terao, A., J.P. Wisor, C. Peyron, A. Apte-Deshpande, S.W. Wurts, D.M. Edgar, and T.S. Kilduff. Gene expression in the rat brain during sleep deprivation and recovery sleep: an Affymetrix GeneChip® study. Neurosci 137:593–605 (2006).

Wisor, J.P., S.R. Morairty, N.T. Huynh, T.L. Steininger, and T.S. Kilduff. Gene expression in the rat cerebral cortex: comparison of recovery sleep and hypnotic-induced sleep. Neurosci 141:371–378 (2006).

Wisor, J.P., W.C. Dement, L. Aimone, M. Williams, and D. Bozyczko-Coyne. Armodafinil, the R-enantiomer of Modafinil: wake-promoting effects and pharmacokinetic profile in the rat. Pharmacol Biochem Behav 85(3):492–9 (2006).

Xie, X.M., T.L. Crowder, A. Yamanaka, S.R. Morairty, R.D. LeWinter, T. Sakurai, and T.S. Kilduff. GABAB receptor-mediated modulation of hypocretin/orexin neurons in mouse hypothalamus. J Physiol 574(2):399–414 (2006).

Yamanaka, A., Y. Muraki, N. Tsujino, T.S. Kilduff, K. Goto, and T. Sakurai. Orexin neurons are directly and indirectly regulated by catecholamines in a complex manner. J Neurophysiol 96:284–98 (2006).

Zaveri, N.T., N.S. Waleh, and L. Toll. Regulation of the prepronociceptin gene and its effect on neuronal differentiation. Gene 384:27–36 (2006).

Abstracts and Presentations

Berzetei-Gurske, I., L. Jimenez, D. Haggart, L. Toll, and F.I. Carroll. Ex-vivo study of long lasting activity of the kappa-antagonist JDTic. College on Problems of Drug Dependence (CPDD) Annual Meeting, Scottsdale, AZ, June 17–22, 2006.

Berzetei-Gurske, I., L. Jimenez, D. Haggart, W. Polgar, L. Toll, and F.I. Carroll. JDTic, a long lasting kappa-antagonist. Neuroscience Annual Meeting, Atlanta, GA, October 14–18, 2006.

Blakely, E.A., P.Y. Chang, K.A. Bjornstad, C.R. Rosen. Expression of ECM genes during human lens fiber cell differentiation in vitro. Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, FL, April 30–May 4, 2006.

Morairty, S., L. Hedley, J. Flores, R. Martin, and T.S. Kilduff. Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats. Sleep 29:A3 (2006).

Morairty, S.R., J. Flores, and T.S. Kilduff. The wake-promoting effects of hypocretin-1 are blunted in aged rats. Sleep 29:A104 (2006).

Mylecharane, E.J., G. Cunningham, D. Haggart, and I. Berzetei-Gurske. 5-HT transporter affinities for pethidine and norpethidine, and their role in serotonin syndrome. College on Problems of Drug Dependence (CPDD) Annual Meeting, Scottsdale, AZ, June 17–22, 2006.

Xie, X.M., T.L. Crowder, T. Sakurai, L. de Lecea, and T.S. Kilduff. Neuropeptide S modulates hypocretin/orexin neurons via pre- and postsynaptic mechanisms in the mouse hypothalamus. Sleep Res APSS, Abst. 013 (2006).

Pharmaceutical Sciences

Abstracts and Presentations

Bejugam, N., H.J. Parish, and G. Shankar. High throughput solubility screening design for formulation optimization of poorly water soluble and water insoluble drugs. American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, San Antonio, TX, October 29–November 2, 2006.

Shankar, G., L. Nguyen, H.J. Parish, and V. Pavuluri. Studying in-vitro intestinal absorption of drugs using Ussing system. American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, San Antonio, TX, October 29–November 2, 2006.

Shankar, G., L. Nguyen, H.J. Parish, M.A. Ussery, and V.R. Pavuluri. Developing an orally-absorbed formulation for Paromomycin. 13th Drug Delivery Symposium, Salt Lake City, Utah, February 18–25, 2006

Physiology

Publications

Asikainen, T.M., L.Y. Chang, J.J. Coalson, B.K. Schneider, N.S. Waleh, M. Ikegami, J.M. Shannon, V.T. Winter, P. Grubb, R.I. Clyman, B.A. Yoder, J.D. Crapo, and C.W. White. Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity. FASEB J 20:1698–700 (2006).

Asikainen, T.M., N.S. Waleh, B.K. Schneider, R.I. Clyman, and C.W. White. Enhancement of angiogenic effectors through hypoxia-inducible factor in preterm primate lung in vivo. Am J Physiol Lung Cell Mol Physiol 291:L588–95 (2006).

Levin, M., D. McCurnin, S.R. Seidner, B. Yoder, N.S. Waleh, S. Goldbarg, C. Roman, B.M. Liu, J. Boren, and R.I. Clyman. Postnatal constriction, ATP depletion, and cell death in the mature and immature ductus arteriosus. Am J Physiol Regul Integr Comp Physiol 290:R359–64 (2006).

Toxicology

Publications

Amin, K., C. Ip, B. Sato, C.E. Green, C.A. Tyson, and H.P. Behrsing. Characterization of ANIT-induced toxicity using precision-cut rat and dog liver slices cultured in a dynamic organ roller system. Toxicologic Pathology 34:776–784, 2006.

Brill, S.S., A.M. Furimsky, M.N. Ho, M.J. Furniss, Y. Li, A.G. Green, W.W. Bradford, C.E. Green, I.M. Kapetanovic, and L.V. Iyer. Glucuronidation of trans-resveratrol by human liver and intestinal microsomes and UGT isoforms. J Pharmacy Pharmacol 58:469–479, 2006.

Doppalapudi, R.S., A. Lin, J. Puey, J. Bakke, and P. Chang. Evaluation of temporal changes in cytogenetic damage in vivo after particle radiation exposure. Environ Mol Mutagen 47 (6):459 (2006).

Verschoyle, R.D., P. Greaves, H. Cai, A. Borkhardt, M. Broggini, M. D’Incalci, E. Riccio, R. Doppalapudi, I.M. Kapetanovic, W.P. Steward, and A.J. Gescher. Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone. Cancer Chemother Pharmacol 57:1–6 (2006).

Waterhouse, R.N., J. Zhao, M.G. Stabin, H. Ng, J. Schindler-Horvat, R.C. Chang, and J. Mirsalis. Preclinical acute toxicity studies and dosimetry estimates of the novel sigma-1 receptor selective radiotracer, [18F]SFE. Mol Imaging and Biol 8:284–291 (2006).

Abstracts and Presentations

Amin, K., C. Ip, T. Le, J.E. Tomaszewski, C.E. Green, C.A. Tyson, and H. Behrsing. Human and rat lung tissue exhibit differential sensitivity to phortress toxicity: use of precision-cut lung slices. Society of Toxicology 45th Annual Meeting, San Diego, CA, March 5–9, 2006.

Behrsing, H., C. Ip, T. Le, J.E. Tomaszewski, C.E. Green, C.A. Tyson, and K. Amin. Demonstration of differential toxicity induced by aminoflavone prodrug in human and rat precision cut lung slices. Society of Toxicology 45th Annual Meeting, San Diego, CA, March 5–9, 2006.

Chang, P.Y., J. Bakke, A. Puey, and S. Lin. Cytogenotoxicity and mutagenesis of fractionated particle radiation in vivo. Radiation Research Society Annual Meeting, Philadelphia, PA, November 5–8, 2006.

Chang, P.Y., J. Bakke, A. Puey, and S. Lin. Particle radiation-induced mutagenesis in vivo. Committee on Space Research (COSPAR) Colloquium on Mutagenic Consequences of the Space Environment, Xi’An, China, July 23–25, 2006.

Chang, P.Y., J. Bakke, A. Puey, and S. Lin. Particle-radiation induced cytogenetic and mutagenic effects in vivo. 4th International Workshop on Space Radiation Research, Moscow/St. Petersburg, Russia, June 5–9, 2006.

Matsuyama, K., S. Difuntorum, J. Milano, L. Olson, M. Tanga, and K. Mortelmans. Antimicrobial agents with activity against several BSL-2 and BSL-3 biodefense organisms. Society for Industrial Microbiology (SIM) Conference, Baltimore, MD, July 30–August 3, 2006.

Rausch, L., A. Robb, P. Catz, S. Levalley, T. Harrison, K. Steinmetz, C. Green, J. Tomaszewski, K. Scheikart, N. Zaveri, J. Mirsalis. Biomarker levels in hormonally sensitive female F-344 rats and beagle dog tissues after treatment with SR16157, a selective estrogen receptor modulator (SERM). American Association for Cancer Research (AACR) 97th Annual Meeting, Washington, D.C., April 1–4, 2006.

Other Publications, Abstracts, and Publications

Barry, S., and W.H. Moos, Eds. Special issue: Nanobiotechnology. Drug Dev Res 67:1–106 (2006).

Barry, S., and W.H. Moos. Nanobiotechnology: It’s a small world after all. Drug Dev Res 67:1–3 (2006).

Moos, W.H. Bridging the valley of death: from idea to IND™. 3rd Annual Florida Tech Transfer Conference, Sarasota, FL, May 22–23, 2006.

Parish, H., R. Key-Schwartz, D. Popp, and T. Hayes. JAI 3:6, e-publication http://journalsip.astm.org/JOURNALS/JAI/PAGES/JAI12243.htm (June 2006).

Patents

Anderson, C.M., R.E. Davis, W. Clevenger, S.E. Wiley, S.W. Miller, T.R. Szabo, S.S. Ghosh, W.H. Moos, and Y. Pei. Production of Adenine Nucleotide Translocator (ANT), Novel ANT Ligands and Screening Assays Therefor. U.S. Patent 7,001,729, February 21, 2006.

Dawson, M.I., P.D. Hobbs, and L. Jong. Induction of Apoptosis in Cancer Cells. U.S. Patent 7053071, May 30, 2006.

Jong, L., and W.-R. Chao. Analogs of Indole-3-Carbinol Metabolites as Chemotherapeutic and Chemopreventive Agents. U.S. Patent 7078427, July 18, 2006.

Toll, L.R., P.D. Lincoln, P.D. Karp, and M.K. Sonmez. Biopolymer Sequence Comparison (US). U.S. Patent 7133781, November 7, 2006.

Toll, L.R., P.D. Lincoln, P.D. Karp, and M.K. Sonmez. Data Relationship Model. U.S. Patent 7039238, May 2, 2006.

Zaveri, N.T., W.-R. Chao, and A. Bensari. Analogs of Green Tea Polyphenols as Chemotherapeutic and Chemopreventive Agents. U.S. Patent 7122573, October 17, 2006.

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