Dr. Gary Swan, Director, Center for Health Sciences

Dr. Swan has been involved in research at SRI International for the past 25 years, serving as the Director of the Center for Health Sciences since 1987.  His research areas of interest include treatment of nicotine dependence, genetic and environmental determinants of addiction and disease, brain aging, and pharmacogenetics. He has been Principal Investigator or Co-Investigator on over twenty NIH-funded grants and has published extensively.

Dr. Swan has been the Editor-in-Chief of the journal Nicotine & Tobacco Research since 1997, and has guided its growth from 40 submissions per year to over 200 in 2004.  The journal has been listed on Index Medicus after its first year of operation, an important milestone for a fledgling journal.

At SRI, Dr. Swan has twice received Professional Excellence Awards in addition to the Fellowship Award, SRI’s highest honor for researchers.  Dr. Swan received his doctorate in psychology from the State University of New York at Stony Brook in 1978 and is a Licensed Psychologist in the state of California. 

Education

Academic Positions / Employment

Honors and Awards

Selected Peer-Reviewed Manuscripts

Carmelli D, Swan GE, Robinette D, Fabsitz RR.  Genetic influence on smoking: A study of male twins.  N Engl J Med, 327:829-833, 1992.

Swan GE, Ward MM, Jack LM, Javitz HS.  Cardiovascular reactivity as a predictor of relapse in male and female smokers.  Health Psychology, 12:451-458, 1993.

Swan GE, Carmelli D, Robinette D.  Characteristics associated with excessive weight gain following smoking cessation in adult males.  Am J Public Health, 85:73-77, 1995.

Swan GE, Ward MM, Carmelli D, Jack LM. The identification of subgroups with differential rates of relapse after cessation of smoking: Implications for alcohol treatment research.  In: Fertig J and Allen JP (Eds.)  NIAAA Alcohol Research Monograph, Alcohol and Tobacco: From Basic Science to Clinical Practice, U.S. Govt. Printing Office: NIH No. 95-3931:239-263, 1995.

Swan GE, Carmelli D, Cardon LR.  The consumption of tobacco, alcohol, and coffee in Caucasian male twins:  A multivariate genetic analysis.  J Substance Abuse, 8:19-31, 1996.

Swan GE, Ward MM, Jack LM. Abstinence effects as predictors of 28-day relapse in smokers. Addictive Behav, 21:481-490, 1996.

Swan GE, Carmelli D.  The genetics of smoking and related issues.  In Noble, E.P., and Blum, K. (Eds).  Handbook of Psychoneurogenetics, CRC Press, pp. 379-398, 1997.

Swan GE, Carmelli D, Cardon LR. Heavy consumption of cigarettes, alcohol, and coffee in male twins. J Studies in Alcohol, 58:182-190, 1997.

Swan GE, Jack LM, Ward MM. Subgroups of smokers with different success rates after use of transdermal nicotine. Addiction, 92:207-218, 1997.

Cheng LS-C, Swan GE, Carmelli DA.  A genetic analysis of smoking behavior in family members of older adult males.  Addiction, 95:427-435, 2000.

Hudmon KS, Marks JL, Pomerleau CS, Bolt DM, Brigham JZ, Swan GE.  A multidimensional model for characterizing tobacco dependence.  Nicotine Tob Res, Oct 2003;5(5):655-664.

Jack LM, Swan GE, Thompson E, Curry SJ, McAfee T, Dacey S, Bergman K. Bupropion SR and smoking cessation in actual practice: methods for recruitment, screening, and exclusion for a field trial in a managed care setting. Prev Med, 36(5):585-593, 2003.

Li MD, Cheng R, Ma JZ, Swan GE. A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. Addiction.98(1):23-31, 2003.

McCaffery JM, Niaura R, Swan GE, Carmelli D.  Depressive symptoms and smoking in the NHLBI Twins.  Nicotine Tob Res, 5:77-83, 2003.

Shenassa ED, McCaffery JM, Swan GE, Khroyan TV, Shakib S, Lerman C, Lyons M, Mouttapa M, Niaura RS, Buka SL, Leslie F, Santangel SL. Intergenerational transmission of tobacco use and dependence: A transdisciplinary perspective. Nicotine Tob Res, Dec 2003;5 Suppl 1:S55-69.

Swan GE, Hudmon KS, Cheng LS, Jack LM, Hemberger K, Carmelli D, Khroyan TV, Ring HZ, Hops H, Andrews JA, Tildesley E, McBride D, Benowitz N, Webster C, Wilhelmsen K, Feiler H, Koenig B, Caron L, Illes J. Environmental and genetic determinants of tobacco use: A multidisciplinary, longitudinal family-based design. Cancer Epidemiol Biomarkers Prev 12:994-1005, 2003.

Swan GE, McAfee T, Jack LM, Curry SJ, Javitz HS, Dacey S, Bergman K. Effectiveness of bupropion SR for smoking cessation in a health care setting: a randomized trial. Arch Int Med 163:2337-2344, 2003.

Swan GE, Jack LM, Curry SJ, Chorost M, Javitz HS, McAfee T, Dacey S. Bupropion SR and counseling for smoking cessation in actual practice: Predictors of outcome.  Nicotine Tob Res 5(6): 911-921, 2003.

Berrettini, W., Bierut, L., Crowley, T. J., Cubells, J. F., Frascella, J., Gelernter, J., Hewitt, J. K., Kreek, M. J., Lachman, H., Leppert, M., Li, M. D., Lachman, H., Leppert, M., Li, M. D., Madden, P., Miner, C., Pollock, J. D., Pomerleau, O., Rice, J. P., Rutter, J. L., Shurtleff, D., Swan, G. E., Tischfield, J. A., Tsuang, M., Uhl, G. R., Vanyukov, M., Volkow, N. D., Wanke, K.,  Setting priorities for genomic research. Science, 2004, 304(5676), 1445-1447.

Javitz, H., Swan, G. E., Zbikowski, S., Curry, S., McAfee, T., Decker, T., Patterson, G., Jack, L. M. Cost-effectiveness of different combinations of bupropion SR dose and behavioral treatment for smoking cessation in a health care setting: A societal perspective. American Journal of Managed Care, 2004, 10(3), 217-226.

Lessov CN, Swan GE, Ring HZ, Khroyan TV, Lerman C.  Genetics and prevention of drug abuse:  Implications for Transdisciplinary research and practice.  Substance Use and Misuse, 39(10-12):1515-69. 2004.

Swan, G. E., Benowitz, N. L., Jacob III, P., Lessov, C. N., Tyndale, R. F., Wilhelmsen, K., Krasnow, R. E., McElroy, M. R., Moore, S. E., Wambach, M. Pharmacogenetics of nicotine metabolism in twins: Methods and procedures. Twin Research, 2004, 7(5), 435-448.

Swan GE, Javitz HS, Jack LM, Curry SJ, McAfee T. Heterogeneity in 12-month outcome among female and male smokers following pharmacobehavioral treatment for smoking cessation in actual practice. Addiction 99:237-250, 2004.

Swan, G. E., Valdes, A. M., Ring, H. Z., Khroyan, T. V., Jack, L. M, Ton, C. C., Curry, S. J., McAfee, T. Dopamine receptor DRD2 genotype and smoking cessation outcome following treatment with bupropion SR. Pharmacogenomics J, 2005;5(1):21-9.

Zbikowski, S. M., Swan, G. E., McClure, J. B. Cigarette smoking and nicotine dependence. In: Reichert, V. C., Talwar, A., Fein, A. M. (eds). Treating tobacco dependence. Medical Clinics of North America, 2004, 88(6), 1453-1465.

Caron, L., Karkazis, K., Raffin, T. A., Swan, G. E., Koenig, B. A. Nicotine addiction through a neurogenomic prism: Ethics, public health, and smoking. Nicotine & Tobacco Research, 2004

Colrain, I. M., Trinder, J., Swan, G. E. The impact of smoking cessation on objective and subjective markers of sleep: Review, synthesis, and recommendations. Nicotine & Tobacco Research, ;6(6), 913-25.

Hudmon, K. S., Pomerleau, C. S., Brigham, J., Javitz, H., Swan, G. E. Validity of retrospective assessments of nicotine dependence: A preliminary report. Addictive Behaviors, Mar 2005;30(3):613-7.

Swan, G. E., Benowitz, N. L., Lessov, C. N., Jacob III, P., Tyndale, R. F., Wilhelmsen, K. Nicotine metabolism: The impact of CYP2A6 on estimates of additive genetic influence. Pharmacogenet Genomics, 2005;15:115-125