Citation
Germano C. Costa, Manoel Otävio da Costa Rocha, Paula Rocha Moreira, Alves Silva Menezes, Micena R. Silva, Kenneth J. Gollob, Walderez O. Dutra, Functional IL-10 Gene Polymorphism Is Associated with Chagas Disease Cardiomyopathy, The Journal of Infectious Diseases, Volume 199, Issue 3, 1 February 2009, Pages 451–454, https://doi.org/10.1086/596061
Abstract
This study was designed to determine whether the functional IL-10 gene polymorphism −1082G/A is associated with the development of cardiomyopathy in individuals infected with Trypanosoma cruzi and whether interleukin (IL)-10 expression can be correlated with patients’ cardiac function. Our results demonstrated that the polymorphic allele, which correlates with lower expression of IL-10, was associated with the development of Chagas disease cardiomyopathy. Accordingly, correlative analysis showed that low IL-10 expression was associated with worse cardiac function, as determined by leftventricular ejection fraction values. Therefore, the IL-10 gene polymorphism and IL-10 expression are important in determining susceptibility to chagasic cardiomyopathy.
Topic:alleles, chagas disease, cardiomyopathy, polymorphism, genes, interleukin-10, interleukins, trypanosoma cruzi, cardiac function, ejection fraction
