Author: Caitlin Tan

  • Synthesis and Optimization of Small Molecule Inhibitors of Prostate Specific Antigen

    We identified a compound as a 216 nM inhibitor of a prostate-specific antigen with better stability in media than triazole B1 and evaluated the selectivity profile of the compound by testing against closely related proteases and demonstrated excellent inhibition of PSA versus α-chymotrypsin and elastase and similar potency versus thrombin.