Author: Peter Karp
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EcoCyc: Electronic Encyclopedia of E. coli Genes and Metabolism
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EcoCyc: The Resource and the Lessons Learned
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Using the EcoCyc Database
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What we do not know about sequence analysis and sequence databases
The marriage of high-throughput nucleotide sequencing with computational methods for the analysis of nucleotide and protein sequences have ushered in a new era of molecular biology.
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A Collaborative Environment for Authoring Large Knowledge Bases
We present an architecture for scalable frame representation systems (FRSs). KBs must be supported for rapid construction by a collaborative effort of teams of knowledge engineers through reuse of existing knowledge and software components.
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Integrated Pathway/Genome Databases and Their Role in Drug Discovery
We describe pathway-based analyses of the genomes of a number of medically relevant microorganisms, and a novel software tool that provides visualization of gene expression data on a diagram showing the whole metabolic network of the microorganism.
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EcoCyc: Electronic Encyclopedia of E. coli Genes and Metabolism
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EcoCyc: Encyclopedia of Escherichia coli genes and metabolism
The encyclopedia of Escherichia coli genes and metabolism (EcoCyc) is a database that combines information about the genome and the intermediary metabolism of E.coli .
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Metabolic Databases
This article will describe some of the uses of these databases and then provide descriptions of the metabolic databases available.
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A Collaborative Environment for Authoring Large Knowledge Bases
Collaborative knowledge base (KB) authoring environments are critical for the construction of high-performance KBs. In this paper, we present an environment that satisfies many of these goals.
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The complete genome sequence of the gastric pathogen Helicobacter pylori
Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification.
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Use of Metabolic Databases to Guide Target Selection for Anti-Microbial Drug Design