Author: Peter Karp

The encyclopedia of Escherichia coli genes and metabolism (EcoCyc) is a database that combines information about the genome and the intermediary metabolism of E.coli .

Collaborative knowledge base (KB) authoring environments are critical for the construction of high-performance KBs. In this paper, we present an environment that satisfies many of these goals.

The Encyclopedia of Genes and Metabolism (EcoCyc) is a database that combines information about the genome and the intermediary metabolism of Escherichia coli.

The GKB Editor is a generic editor and browser of knowledge bases (KBs) and ontologies – generic in the sense that it is portable across several frame knowledge representation systems (FRSs).

Group contribution methods are frequently used for estimating physical properties of compounds from their molecular structures. An algorithm for estimating Gibbs energies of formation through group contribution methods has been automated in an object-oriented framework.

We describe a novel approach for predicting the function of a protein from its amino-acid sequence.

Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification.

The Encyclopedia of E. coli Genes and Metabolism (EcoCyc) is a database that combines information about the genome and the intermediary metabolism of E. coli.

We present a methodology for predicting the metabolic pathways of an organism from its genomic sequence.

We have developed a Web server tool, written in Common Lisp, that allows existing graphical user interface applications written using the Common Lisp Interface Manager (CLIM) to hook easily into the WWW.

This article provides an overview of the DB-interoperation problem, and offers several solutions. It discusses how links are used in molecular biology DBs, and describes the potential stumbling blocks when DB links are created and used.