Biomedical sciences publications
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Biodistribution of the Multidentate Hydroxypyridinonate Ligand [(14) C]-3,4,3-Li(1,2-HOPO), a Potent Actinide Decorporation Agent
The pharmacokinetics and biodistribution of the 14C-labeled actinide decorporation agent 3,4,3-LI(1,2-HOPO) were investigated in young adult Swiss Webster mice and Sprague Dawley rats, after intravenous, intraperitoneal, and oral dose administration.
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Characterization of cyclic peptides containing disulfide bonds
Three peptides that belong to this category, p-Cl-Phe-DPDPE, DPDPE, and CTOP, were analyzed and the results are presented in this paper.
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Practical Measures of Learning Behaviors
This paper argues that improving learning reliably and at scale requires a specific orientation toward measurement, understood broadly.
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High Frequency Neuronal Oscillations in a Cynomolgus Macaque Test of Working Memory Following NMDA Receptor Antagonism
Disruptions in sensory processing and abnormal temporal integration of neuronal oscillations have been identified in schizophrenic patients and may contribute to poor performance in working memory task testing.
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Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers Despite Associations with Baseline Smoking
We observed no significant associations between CHRNA5-A3-B4 variants and smoking cessation, despite replicating previous associations with baseline tobacco consumption.
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Reduced Cerebral and Cardiovascular Hemodynamics During Sustained Affective Stimulation in Young Women with Chronic Low Blood Pressure
We assessed central and peripheral hemodynamic changes in 15 undergraduate women with chronic hypotension and 15 normotensive controls during sustained exposure to pleasant, unpleasant and neutral pictures.
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Biomarkers of Response to Smoking Cessation Pharmacotherapies: Progress to Date
Recent research has begun to determine biomarkers (such as genotype, nicotine and metabolite levels, and brain imaging findings) that may have utility in predicting smoking cessation.
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Discovery of the First Small-Molecule Opioid Pan Antagonist with Nanomolar Affinity at Mu, Delta, Kappa, and Nociceptin Opioid Receptors
Since this is the first ligand containing the trans-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist pharmacophore to have affinity for the NOP receptor, we explored the structural determinants of its NOP binding affinity.
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Pharmacology of Basimglurant (RO4917523, RG7090), a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression
Here, the comprehensive preclinical pharmacological profile of basimglurant is presented with a focus on its therapeutic potential for MDD and drug-like properties.
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Interaction between Reproductive Hormones and Physiological Sleep in Women
This study aimed to assess the interaction between physiological sleep and reproductive hormone measures in perimenopausal women.
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AT-1001: A High-Affinity alpha3beta4 nAChR Ligand with Novel Nicotine-Suppressive Pharmacology
The aim of this study was to investigate the mechanism of action underlying the nicotine-suppressive effects of AT-1001.
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Unravelling Glucan Recognition Systems by Glycome Microarrays Using the Designer Approach and Mass Spectrometry
We describe construction of a "glucome" microarray, the first sequence-defined glycome-scale microarray, using a "designer" approach from targeted ligand-bearing glucans in conjunction with a novel high-sensitivity mass spectrometric sequencing method.