Biomedical sciences publications
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Biological Effectiveness of Photons and Electrons as a Function of Energy
Because of the enormous complexity of the phenomena involved, it is unlikely that any single area of study can provide a clear understanding of the relative biological effectiveness of different…
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Homeostatic Sleep Pressure Is the Primary Factor for Activation of Cortical nNOS/NK1 Neurons
Cortical interneurons, immunoreactive for neuronal nitric oxide synthase (nNOS) and the receptor NK1, express the functional activity marker Fos selectively during sleep. NREM sleep ‘pressure’ is hypothesized to accumulate...
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Varenicline Enhances Dopamine Release Facilitation More Than Nicotine after Long-Term Nicotine Treatment and Withdrawal
Here, we used real-time cyclic voltammetry in brain slices containing the nucleus accumbens to further elucidate the changes in dopamine release linked to nicotine withdrawal.
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Future Approaches to Therapeutic Hypothermia: A Symposium Report
The current session demonstrates the use of wireless technologies for monitoring several physiological variables in freely moving rodents, and reviews advances in analytical techniques for the detection of adenosine which…
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Plasmodium vivax trophozoite-stage proteomes
Data from two of three biological replicate proteomes, emphasized here, were analyzed using five search engines, which enhanced identifications and resulted in the most comprehensive P. vivax proteomes to date.
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Methods of Association and Dissociation for Establishing Selective Brain-Behavior Relations
Methods for identifying and understanding brain structure–function relations have evolved over the past century, from astute observations of selective impairments associated with focal brain damage to dissociations measured by combining…
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Tablet formulation of an active pharmaceutical ingredient with a sticking and filming problem: direct compression and dry granulation evaluations
Direct compression and dry granulation tableting techniques were evaluated using factorial experimental design.
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Introduction of plasmid encoding for rare tRNAs reduces amplification bias in phage display biopanning
Here we present a method that reduces amplification bias by addition of a plasmid that encodes six low abundance tRNAs into K91 Escherichia coli.
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The Acute Effects of Alcohol on Sleep Electroencephalogram Power Spectra in Late Adolescence
Background Alcohol’s effect on sleep electroencephalogram (EEG) power spectra during late adolescence is of interest given that this age group shows both dramatic increases in alcohol consumption and major sleep-related…
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Characterization, HPLC Method Development and Impurity Identification for 3,4,3-Li(1,2-HOPO), a Potent Actinide Chelator for Radionuclide Decorporation
Derivatization of the target ligand in situ with Fe(III) chloride provided a single homogeneous iron-complex that can readily be detected and analyzed by HPLC.
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Cytotoxicity of Human Endogenous Retrovirus K-Specific T Cells toward Autologous Ovarian Cancer Cells
Endogenous retroviral gene products in ovarian cancer may represent a potentially valuable new pool of tumor-associated antigens for targeting of therapeutic vaccines to ovarian cancer.
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Measuring and Statistically Testing the Size of the Effect of a Chemical Compound on a Continuous in-Vitro Pharmacological Response through a New Statistical Model of Response Detection Limit
We used a linearized version of this equation to define a measure of pharmacological effect size, and use this measure to rank the investigated compounds in order of their overall…