Biomedical sciences publications

The main objective of this investigation was to study the feasibility of developing a vaginal bioadhesive microbicide using a SRI’s proprietary two-polymer gel platform (SR-2P).

The presence of physiological hot flashes accounts for a significant proportion of total objective time awake during the night in perimenopausal women.

We evaluated chr6q25.3 organic cation transporter gene (SLC22A1, SLC22A2, SLC22A3) variation and response to smoking cessation therapies.

Using a peer nomination technique in a sample of incarcerated females, our study is the first to examine the association between peer status and psychopathology in a correctional facility.

We show that TRIM56 poses a barrier to infections by yellow fever virus (YFV), dengue virus serotype 2 (DENV2), and human coronavirus virus (HCoV) OC43 but not encephalomyocarditis virus (EMCV).

Over-the-counter access to an inexpensive, effective topical microbicide could reduce the transmission of HIV and would increase women’s control over their health and eliminate the need to obtain their partners’…

Here, using docking simulation and site-directed mutagenesis, we defined Tyr-308 as the key amino acid residue on β2-AR essential for Gs-biased signaling.

We evaluated time to clearance of high risk (HR) HPV infection in relation to functional variants in three genes (CYP1A1, GSTT1, and GSTM1).

This paper reports on the pharmacokinetics and toxicokinetics of compound 1 and the relevance of these findings with respect to further development of this integrase-targeted antiviral agent.

To understand the mechanism through which α6β2* nAChRs regulate L-dopa-induced AIMs, we used gain-of-function α6* nAChR (α6L9’S) mice. This mutation results in enhanced sensitivity to nicotine/acetylcholine and prolonged receptor-mediated activity.

We report here that USP8/UBPY, a deubiquitinating enzyme not previously implicated in mitochondrial quality control, is critical for parkin-mediated mitophagy.

Objective: To evaluate whether biases may influence the findings of whole-brain structural imaging literature.