Biomedical sciences publications
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Role for the Nicotinic Cholinergic System in Movement Disorders; Therapeutic Implications
This work raised the question whether dysregulation of this system may contribute to motor dysfunction and whether drugs targeting nicotinic acetylcholine receptors (nAChRs) may be of therapeutic benefit in movement…
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A Lower Degree of PBMC L1 Methylation in Women with Lower Folate Status May Explain the MTHFR C677T Polymorphism Associated Higher Risk of CIN in the US Post Folic Acid Fortification
It is unknown whether exposure to higher folate as a result of the FA fortification program has altered the association between MTHFR C677T and risk of CIN, or the mechanisms…
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Cognition, Emotion, and Attention
This review elucidates the concepts of attention, emotion, and cognition and references research on the underlying neural networks and their compromise in alcohol use disorder.
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Structural and Microstructral Imaging of the Brain in Alcohol Use Disorders
This review focuses on MRI and DTI findings in common concomitants of alcoholism and also covers findings in abstinence and relapse.
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Development of a Novel Bioadhesive Microbicide Gel Formulation for Prophylactic Protection against Hiv and Hsv-2
Over-the-counter access to an inexpensive, effective topical microbicide could reduce the transmission of HIV and would increase women’s control over their health and eliminate the need to obtain their partners’…
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Identification of a Novel Lysosomal Trafficking Peptide Using Phage Display Biopanning Coupled with Endocytic Selection Pressure
We performed phage display biopanning on cancer cells that are treated with selective inhibitors of a given mechanism of endocytosis.
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Impaired Off-Line Motor Skills Consolidation in Young Primary Insomniacs
Here we assessed the sleep-related off-line consolidation of motor skills in 13 young primary insomniacs compared to 13 healthy sleepers using the sequential finger tapping task.
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New Candidate Biomarkers in the Female Genital Tract to Evaluate Microbicide Toxicity
Vaginal microbicides hold great promise for the prevention of viral diseases like HIV, but the failure of several microbicide candidates in clinical trials has raised important questions.
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Structure-Based Virtual Screening of the Nociceptin Receptor: Hybrid Docking and Shape-Based Approaches for Improved Hit Identification
In this study, we explored the use of the active-state NOP homology model for structure-based virtual screening to discover NOP ligands containing new chemical scaffolds.
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Alcohol and the Sleeping Brain
This chapter outlines the evidence for acute and chronic alcohol effects on sleep architecture and sleep electroencephalogram, evidence for tolerance with repeated administration, and possible underlying neurochemical mechanisms for alcohol's…
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Human Endogenous Retrovirus K Expression Predicts a Prostate Cancer Diagnosis
This review will summarize the current state of knowledge regarding HERV-K and cancer and attempt to outline the potential mechanisms by which HERV-K could be involved in the onset and…
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Nocturnal Cardiac Autonomic Profile in Young Primary Insomniacs and Good Sleepers
We investigated cardiac vagal and sympathetic activity in 13 young primary insomniacs and 14 good sleepers during nocturnal sleep.