Biomedical sciences publications
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Inhibition or Knockdown of ABC Transporters Enhances Susceptibility of Adult and Juvenile Schistosomes to Praziquantel
We show that the activity of PZQ against schistosome adults and juveniles ex vivo is potentiated by co-administration of either the highly potent Pgp inhibitor tariquidar or combinations of inhibitors…
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Gender Difference in Interactions between MAOA Promoter uVNTR Polymorphism and Negative Familial Stressors on Body Mass Index among Chinese Adolescents
Our goals were to replicate the population effects of this functional polymorphism on obesity risk, and to further explore gender differences and interaction effects with negative stressors.
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Role for the Nicotinic Cholinergic System in Movement Disorders; Therapeutic Implications
This work raised the question whether dysregulation of this system may contribute to motor dysfunction and whether drugs targeting nicotinic acetylcholine receptors (nAChRs) may be of therapeutic benefit in movement…
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Cognition, Emotion, and Attention
This review elucidates the concepts of attention, emotion, and cognition and references research on the underlying neural networks and their compromise in alcohol use disorder.
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A Lower Degree of PBMC L1 Methylation in Women with Lower Folate Status May Explain the MTHFR C677T Polymorphism Associated Higher Risk of CIN in the US Post Folic Acid Fortification
It is unknown whether exposure to higher folate as a result of the FA fortification program has altered the association between MTHFR C677T and risk of CIN, or the mechanisms…
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Structural and Microstructral Imaging of the Brain in Alcohol Use Disorders
This review focuses on MRI and DTI findings in common concomitants of alcoholism and also covers findings in abstinence and relapse.
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Development of a Novel Bioadhesive Microbicide Gel Formulation for Prophylactic Protection against Hiv and Hsv-2
Over-the-counter access to an inexpensive, effective topical microbicide could reduce the transmission of HIV and would increase women’s control over their health and eliminate the need to obtain their partners’…
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Identification of a Novel Lysosomal Trafficking Peptide Using Phage Display Biopanning Coupled with Endocytic Selection Pressure
We performed phage display biopanning on cancer cells that are treated with selective inhibitors of a given mechanism of endocytosis.
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Impaired Off-Line Motor Skills Consolidation in Young Primary Insomniacs
Here we assessed the sleep-related off-line consolidation of motor skills in 13 young primary insomniacs compared to 13 healthy sleepers using the sequential finger tapping task.
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New Candidate Biomarkers in the Female Genital Tract to Evaluate Microbicide Toxicity
Vaginal microbicides hold great promise for the prevention of viral diseases like HIV, but the failure of several microbicide candidates in clinical trials has raised important questions.
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The Feasibility of Assessing Branched-Chain Amino Acid Metabolism in Cellular Models of Prostate Cancer with Hyperpolarized [1-(13)C]-Ketoisocaproate
Our goals were to investigate branched-chain aminotransferase (BCAT) activity in prostate cancer with a novel molecular probe, hyperpolarized [1-(13)C]-2-ketoisocaproate ([1-(13)C]-KIC), and explore the potential of branched-chain amino acid (BCAA) metabolism…
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Representing Roles in a Biology Textbook
In this paper, we consider the roles in a biology textbook, adapt a definition of roles based on upper ontologies, and relate it to the corresponding notions in linguistics and…