Biomedical sciences publications
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Development of an Agonist of the TGF-Beta Signaling Pathway to Treat Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder that leads to progressive cognitive dysfunction. Current knowledge of the processes leading to AD is still limited, and no effective treatments are available.…
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5′-AMP-Activated Protein Kinase (AMPK) Supports the Growth of Aggressive Experimental Human Breast Cancer Tumors
Here, we used triple-negative human breast cancer cells in which AMPK activity had been knocked down to investigate the contribution of AMPK to experimental tumor growth and core glucose metabolism.
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Building a Breathprint: Biomarkers of Exposure Due to the Toxicant Trochloroethylene
Our pilot studies indicate that we can detect TCE and other VOCs in the breath environment that are indicative of neuronal degeneration. Pending studies will investigate the relationship between toxicant exposure…
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Cortical nNOS/NK1 Neurons Are Regulated by Cholinergic Inputs
CCh has a network effect on excitability within the cortex, as both presynaptic and postsynaptic effects result in an oscillating pattern of nNOS/NK1 neuron excitability.
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White Matter Microstructural Recovery with Abstinence and Decline with Relapse in Alcohol Dependence Interacts with Normal Ageing: A Controlled Longitudinal DTI Study
Background Alcohol dependence exacts a toll on brain white matter microstructure, which has the potential of repair with prolonged sobriety. Diffusion tensor imaging (DTI) enables in-vivo quantification of tissue constituents…
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Accelerated Aging of Selective Brain Structures in Human Immunodeficiency Virus Infection: A Controlled, Longitudinal Magnetic Resonance Imaging Study
Infected individuals are living long enough that there is a potential for interaction with normal senescence effects on various organ systems, including the brain. To examine this interaction, the brains…
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Evaluation of Functional Activity and Aggregation Properties of Hemopressin
We tested the hemopressin peptide for CB1 receptor agonist and antagonist activity in cAMP and β-arrestin recruitment assay and found it to be inactive.
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Effects of Nicotine Deprivation and Replacement on Bold-Fmri Response to Smoking Cues as a Function of DRD4 Vntr Genotype
INTRODUCTION: Reactivity to smoking cues is an important factor in the motivation to smoke and has been associated with the dopamine receptor 4 variable number tandem repeat (DRD4 exon III…
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N-CANDA Data Integration: Anatomy of an Asynchronous Infrastructure for Multi-Site, Multi-Instrument Longitudinal Data Capture
The concepts implemented in N-CANDA’s data collection system helped reduce project start-up time by several months.
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Dynamic Metabolic Imaging of Hyperpolarized [2-C-13]Pyruvate Using Spiral Chemical Shift Imaging with Alternating Spectral Band Excitation
This study introduces a sequence for three-dimensional CSI of [2-(13) C]pyruvate using spectrally selective excitation of limited frequency bands containing a subset of metabolites. Dynamic CSI data were acquired alternately…
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The Acute and Chronic Effects of Alcohol Consumption on Sleep Architecture in College Aged Students
This study examined the effect of alcohol on sleep architecture in women and men aged 18 to 21 years and whether previously reported sleep architecture effects may have been as…
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Association between Personality Traits and DSM-IV Diagnosis of Insomnia in Peri- and Postmenopausal Women
The aim of this study was to determine the role of personality factors in the development of DSM-IV insomnia coincident with perimenopause.