Biomedical sciences publications
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Effect of Bitopertin, a Glycine Reuptake Inhibitor, on Negative Symptoms of Schizophrenia: A Randomized, Double-Blind, Proof-of-Concept Study
Our objective is to determine the efficacy and safety of bitopertin (RG1678), a glycine reuptake inhibitor, in patients with schizophrenia and predominant negative symptoms who were stable while taking an…
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Evidence of Recovery in Cortico-Cardiac Activity During Sleep in Recently Detoxified Alcoholics
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Sleep EEG Evidence of Early Brain Recovery with Abstinence in Long-Term Alcoholics
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Time to Smoke First Morning Cigarette and Lung Cancer in a Case-Control Study
We evaluated whether time to first cigarette after waking, a single-item measure of nicotine dependency, could improve stratification of lung cancer risk beyond standard smoking metrics.
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Deuterium Protection of Polyunsaturated Fatty Acids against Lipid Peroxidation: A Novel Approach to Mitigating Mitochondrial Neurological Diseases
Oxidative stress is associated with numerous neurological disorders. Mitochondrial malfunction contributes to generation of reactive oxygen species (ROS) in proximity to mitochondrial membranes rich in polyunsaturated fatty acids (PUFAs). ROS…
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Brain Connectivity Changes over Time in Alcoholism
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Heterogeneity of Alcohol Effects on Nodes of Frontocerebellar and Limbic Circuitry: Evidence from the US-France Collaborative Study
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Sample Collection in Clinical Proteomics – Proteolytic Activity Profile of Serum and Plasma
We utilized the platform to ascertain the impact of three commonly used anticoagulants (EDTA, heparin, and citrate) on the proteolytic activity profile of plasma and serum collected from a healthy…
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Permeability Enhancing Lipid-Based Co-Solvent and SEDDS Formulations of SQ641, an Antimycobacterial Agent
The objective of this study was to develop an oral preclinical liquid formulation of SQ641 and to determine the permeability across rat intestinal tissue by Ussing chamber.
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In Vivo Diffusion Tensor Imaging Evidence for Reversible White Matter Microstructural Integrity Disruption: Effects of Abstinence in Rat and Man
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Design and Synthesis of Molecular Probes for the Determination of the Target of the Anthelmintic Drug Praziquantel
In this Letter, we report an efficient protocol for the small-scale separation of enantiomers of 2 (hydrolyzed PZQ) using supercritical fluid chromatography (SFC).
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Sobriety Length and Lifetime Alcohol Consumption Modulate Brain Response to Emotional Faces and Alcohol Pictures in Abstinent Alcoholics