Biomedical sciences publications
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Sample Collection in Clinical Proteomics – Proteolytic Activity Profile of Serum and Plasma
We utilized the platform to ascertain the impact of three commonly used anticoagulants (EDTA, heparin, and citrate) on the proteolytic activity profile of plasma and serum collected from a healthy…
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Permeability Enhancing Lipid-Based Co-Solvent and SEDDS Formulations of SQ641, an Antimycobacterial Agent
The objective of this study was to develop an oral preclinical liquid formulation of SQ641 and to determine the permeability across rat intestinal tissue by Ussing chamber.
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In Vivo Diffusion Tensor Imaging Evidence for Reversible White Matter Microstructural Integrity Disruption: Effects of Abstinence in Rat and Man
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Global Ethics and Virtual Worlds: Ensuring Functional Integrity in Transnational Research Studies
This paper examines a number of issues in this research context, with particular stress on the challenges posed by transnational experimental projects in virtual worlds and social networks.
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Optogenetic Manipulation of Activity and Temporally Controlled Cell-Specific Ablation Reveal a Role for MCH Neurons in Sleep/Wake Regulation
To determine the physiological role of MCH neurons, newly developed transgenic mouse strains that enable manipulation of the activity and fate of MCH neurons in vivo were generated using the…
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Dissociation of Preparatory Attention and Response Monitoring Maturation During Adolescence
The objective was to assess development of EEG markers of these strategies and their role in both preparatory attention (contingent negative variation, CNV) and response monitoring (Error Related Negativity, ERN,…
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The 24-H Progression of Menstrual Pain in Women with Primary Dysmenorrhea When Given Diclofenac Potassium: A Randomized, Double-Blinded, Placebo-Controlled Crossover Study
We aimed to investigate the efficacy of the daily recommended dose of diclofenac potassium in treating severe menstrual pain in women with severe primary dysmenorrhea.
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Nicotine Dependence as a Moderator of Genetic Influences on Smoking Cessation Treatment Outcome
In this secondary analysis of clinical trial data, we examined nicotine dependence severity as a moderator of the effects of 1198 single nucleotide polymorphisms (SNPs) in 53 biologically-relevant gene regions…
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Design of a Peptide Inhibitor of Tyrosine Kinase 2
The development of antisense peptide inhibitors is a relatively unexplored area of research, and here we investigate inhibitory peptides specific for the Janus-associated kinase (JAK) family member, tyrosine kinase 2 (TYK2).
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GABAB Agonism Promotes Sleep and Reduces Cataplexy in Murine Narcolepsy
We evaluated the effects of chronic administration of GHB and the GABA B agonist R -baclofen ( R -BAC) on arousal state and cataplexy in two models of narcolepsy: orexin/ataxin-3…
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The Adaptor Protein SAP Regulates Type II NKT-Cell Development, Cytokine Production, and Cytotoxicity against Lymphoma
Here, using a type II NKT-cell TCR transgenic mouse model, we demonstrated that CD1d-expressing hematopoietic cells, but not thymic epithelial cells, meditate efficient selection of type II NKT cells.
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Poor Autonomic Nervous System Functioning During Sleep in Recently Detoxified Alcohol-Dependent Men and Women
We investigated nighttime ANS functioning, and the relation between ANS activity and severity of alcohol dependence in chronic alcoholism.