Biomedical sciences publications
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[1-125]AT-1012, a New High Affinity Radioligand for the α3β4 Nicotinic Acetylcholine Receptors
We report here the vitro characterization of this radioligand in receptor binding and in vitro autoradiographic studies targeting the α3β4* nAChR.
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Evaluating the Toxicity of Novel Zn-DTPA Tablet Formulation in Dogs and Rats
The purpose of this research work is to evaluate toxicity of diethylenetriamine pentaacetic acid zinc trisodium salt (Zn-DTPA) tablets.
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Reduced Quality of Life When Experiencing Menstrual Pain in Women with Primary Dysmenorrhea
We investigated whether QoL varies between women with and without severe primary dysmenorrhea, and whether QoL is impaired only during menstruation or also during pain-free phases of the menstrual cycle.
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HPLC Method Development, Validation and Impurity Characterization for an Antitumor Hsp90 Inhibitor-PU-H71 (NSC 750424)
An HPLC method for the assay of the heat shock protein 90 inhibitor, PU-H71 (NSC 750424), has been developed and validated.
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Glyco-Epitope Diversity: An Evolving Area of Glycomics Research and Biomarker Discovery
Tumor glycomics research in recent years has uncovered a large panel of tumor-associated carbohydrate antigens and evidence of immune recognition of tumor-derived aberrant carbohydrates.
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Human Imaging Studies of Brain Circuitry Disrupted by Alcoholism
Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence.
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A Tailoring Algorithm to Optimize Behavior Change
A new algorithm, developed with data from smoking cessation clinical trials and published practice guidelines, is designed to predict the likelihood of abstinence.
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Gene-Environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson’s Disease
Here we describe the use of a neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which produces a nigrostriatal lesion to elucidate the distinct contributions of LOX isozymes to neurodegeneration related to PD.
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Rat Strain Differences in Brain Structure and Neurochemistry in Response to Binge Alcohol
Here, alcohol-preferring (P) and alcohol-nonpreferring (NP) rats systematically bred from heterogeneous stock Wistar rats for differential alcohol drinking behavior were compared with Wistar rats to determine whether genetic divergence and…
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Vapor Pressure of Thiodiglycol
The new TDG vapor pressure data are in sharp contrast to widely accepted values from previous literature.
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Biological Barriers and Current Strategies for Modifying Nanoparticle Bioavailability
This paper reviews the anatomy of the primary organs (kidney, liver, and spleen) responsible for nanoparticle bioelimination and the components of the innate immune system (complement system and scavenger receptors)…
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Biomarkers in Pharmacology and Drug Discovery
The relative utility of single biomarkers compared to biomarker panels is discussed, along with paradigms for biomarker development, the latter in the context of three large-scale biomarker consortia, the Critical…