Biomedical sciences publications
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Glyco-Epitope Diversity: An Evolving Area of Glycomics Research and Biomarker Discovery
Tumor glycomics research in recent years has uncovered a large panel of tumor-associated carbohydrate antigens and evidence of immune recognition of tumor-derived aberrant carbohydrates.
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Computational Models for Neglected Diseases: Gaps and Opportunities
Here, we identify gaps in which computational approaches have been used for some neglected diseases and not others. We also make recommendations for the broad-spectrum integration of these techniques into…
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Developments in Purification Methods for Obtaining and Evaluation of Collagen Derived Endogenous Angioinhibitors
This review focuses on the method developments in obtaining biologically active NC1 domains and for specific evaluations in different scenarios.
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Radiation Drugs – Still a Hot Topic
On the occasion of the second anniversary of the Fukushima disaster, it was reported inScience magazine that evacuees were still waiting to go home, but fortunately that radionuclide exposure, at…
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Working Memory Impairment and Cardiovascular Hyperarousal in Young Primary Insomniacs
We investigated memory performance and cardiovascular activity in 13 primary insomniacs (PI) compared to 13 good sleepers (GS).
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Gene-Environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson’s Disease
Here we describe the use of a neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which produces a nigrostriatal lesion to elucidate the distinct contributions of LOX isozymes to neurodegeneration related to PD.
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Rat Strain Differences in Brain Structure and Neurochemistry in Response to Binge Alcohol
Here, alcohol-preferring (P) and alcohol-nonpreferring (NP) rats systematically bred from heterogeneous stock Wistar rats for differential alcohol drinking behavior were compared with Wistar rats to determine whether genetic divergence and…
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Vapor Pressure of Thiodiglycol
The new TDG vapor pressure data are in sharp contrast to widely accepted values from previous literature.
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Biological Barriers and Current Strategies for Modifying Nanoparticle Bioavailability
This paper reviews the anatomy of the primary organs (kidney, liver, and spleen) responsible for nanoparticle bioelimination and the components of the innate immune system (complement system and scavenger receptors)…
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Biomarkers in Pharmacology and Drug Discovery
The relative utility of single biomarkers compared to biomarker panels is discussed, along with paradigms for biomarker development, the latter in the context of three large-scale biomarker consortia, the Critical…
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Comparative Molecular Field Analysis of Fenoterol Derivatives Interacting with an Agonist-Stabilized Form of the β(2)-Adrenergic Receptor
The β2-adrenergic receptor (β2-AR) agonist [3H]-(R,R′)-methoxyfenoterol was employed as the marker ligand in displacement studies measuring the binding affinities (Ki values) of the stereoisomers of a series of 4′-methoxyfenoterol analogs in…
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Design of a Serum Stability Tag for Bioactive Peptides
Here we explored a possibility of designing a serum stability tag made of natural amino acids. We observed that a diproline motif (-Pro-Pro-) shows remarkable stability against serum endopeptidases.