Biomedical sciences publications
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Targeting Inhibitor 2 of Protein Phosphatase 2A as a Therapeutic Strategy for Prostate Cancer Treatment
In this study we hypothesized that targeting the inhibition of I2PP2A’s multiple functions in prostate cancer cells might prevent cancer progression.
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A Selective Insular Perfusion Deficit Contributes to Compromised Salience Network Connectivity in Recovering Alcoholic Men
We propose that attenuated insular CBF is a mechanism underlying compromised connectivity among salience network nodes. This local perfusion deficit in alcoholics has the potential to impair ability to switch…
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Pharmacokinetics and Toxicity of a Neuroprotective Cembranoid
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Working Memory Performance and Cardiovascular Activity in Young Primary Insomniacs
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Suppression of Inflammation with Conditional Deletion of the Prostaglandin E2 EP2 Receptor in Macrophages and Brain Microglia
We investigated the cell-specific in vivo function of PGE2 signaling through its E-prostanoid 2 (EP2) receptor in murine innate immune responses systemically and in the CNS.
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Measuring Mitochondrial Metabolism in Rat Brain in Vivo Using Mr Spectroscopy of Hyperpolarized [2-C-13]Pyruvate
In this study, single-time-point chemical shift imaging data were acquired from rat brain in vivo. [5-13C]Glutamate, [1-13C]acetylcarnitine and [1-13C]citrate were detected in addition to resonances from [2-13C]Pyr and [2-13C]Lac.
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Nicotinic Receptor Agonists Reduce l-DOPA–Induced Dyskinesias in a Monkey Model of Parkinson’s Disease
Here, we investigated whether nicotinic acetylcholine receptor (nAChR) agonists reduced LIDs in nonhuman primates.
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Comparison of Neutralizing Abilities of Human Monoclonal Antibodies Binding Different Epitopes on Botulinum Neurotoxin A
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Multiple CNS Nicotinic Receptors Mediate L-Dopa-Induced Dyskinesias: Studies with Parkinsonian Nicotinic Receptor Knockout Mice
Accumulating evidence supports the idea that drugs acting at nicotinic acetylcholine receptors (nAChRs) may be beneficial for Parkinson's disease.
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Use of CFU-GM Assay to Determine Radiation-Induced Hematotoxicity in Mice
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Influence of Inhibitory Serotonergic Inputs to Orexin/Hypocretin Neurons on the Diurnal Rhythm of Sleep and Wakefulness
Inhibitory serotonergic input likely contributes to wakefulness bouts, affecting the diurnal rhythm of sleep and wakefulness.
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A Multicenter Evaluation of Oral Pressure Therapy for the Treatment of Obstructive Sleep Apnea
We aimed to evaluate the impact of a novel noninvasive oral pressure therapy (OPT) (Winx®, ApniCure) system on polysomnographic measures of sleep-disordered breathing, sleep architecture, and sleep stability in obstructive…