Biomedical sciences publications
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Association of CD28 and CTLA-4 Gene Polymorphisms with Aggressive Periodontitis in Brazilians
Our hypothesis is that polymorphisms in genes that code for these molecules may be associated with periodontitis. The aim of the study was to investigate the association between +17 (T/C) CD28 and…
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Microglial Beclin 1regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease
Here we show that the autophagy protein beclin 1 is required for efficient phagocytosis in vitro and in mouse brains. Interestingly, microglia isolated from human Alzheimer’s disease (AD) brains show significantly…
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A Zero CO2-Emitting Process for Transportation Fuels from Coal and Natural Gas Resources
Simultaneous steam reforming of natural gas and conversion of coal to syngas was achieved in a gas-blown, electrically heated, entrained-flow gasifier. Conversions > 95% for both coal and natural gas…
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Outcomes from a Patient-Centered Residential Treatment Plan for Tobacco Dependence
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Interactive Retinal Vessel Extraction by Integrating Vessel Tracing and Graph Search
We propose an interactive approach that enables a user to efficiently obtain near perfect vessel segmentation with a few mouse clicks. Given two seed points, the approach seeks an optimal…
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Novel Human Radiation Exposure Biomarker Panel Applicable for Patient Triage
A panel of only three proteins is sufficient to accurately distinguish an individual that was exposed to low-levels of ionizing radiation from an unexposed person. These findings have significant implications…
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Exposure to Bisphenol-A Alters Mammary Gland Development and Increases Breast Cancer Risk
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Use of CFU-GM Assay to Determine Radiation-Induced Hematotoxicity in Mice
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Influence of Inhibitory Serotonergic Inputs to Orexin/Hypocretin Neurons on the Diurnal Rhythm of Sleep and Wakefulness
Inhibitory serotonergic input likely contributes to wakefulness bouts, affecting the diurnal rhythm of sleep and wakefulness.
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The Solar Orbiter Imager (SoloHI) Instrument for the Solar Orbiter Mission
We present the design and pre-launch performance of the Solar Orbiter Heliospheric Imager (SoloHI) which is an instrument prepared for inclusion in the ESA/NASA Solar Orbiter mission, currently scheduled for…
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Prolyl Endopeptidase Activity in Bronchoalveolar Lavage Fluid: A Novel Diagnostic Biomarker in a Guinea Pig Model of Invasive Pulmonary Aspergillosis
We are investigating secreted fungal proteases as novel biomarkers for the diagnosis of invasive pulmonary aspergillosis.
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Blocking the B7-H4 Pathway with Novel Recombinant Antibodies Enhances T Cell-Mediated Antitumor Responses
We have recently demonstrated that the expression of B7-H4 on the surface of malignant cells in vivo is inducible, and that novel anti-B7-H4 recombinant antibodies can reverse the inhibition of…