Biomedical sciences publications
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In Vivo Glutamate Measured with Magnetic Resonance Spectroscopy: Behavioral Correlates in Aging
To investigate the contribution of regional glutamate levels to behavior in the aging brain, we used an in vivo magnetic resonance spectroscopy protocol optimized for glutamate detection in 3 brain regions targeted by…
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Development of Functional Assays for p97/VCP Inhibition
We used p97 siRNA and a recently identified small molecule p97 inhibitor, N2,N4-dibenzylquinazoline- 2,4-diamine (DBeQ) as tools to develop functional assays suitable for further evaluating the activity of potential p97…
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The Ability of Plasma Cotinine to Predict Nicotine and Carcinogen Exposure Is Altered by Differences in CYP2A6: The Influence of Genetics, Race, and Sex
Cotinine, a nicotine metabolite, is a biomarker of tobacco, nicotine, and carcinogen exposure. However, a given cotinine level may not represent the same tobacco exposure; for example, African-Americans have higher…
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Preparation and Spectroscopic Characterization of Chemical Derivatives of Lawsone: Novel Reagents to Detect Fingerprints
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Serum Biomarkers Reveal Long-Term Cardiac Injury in Isoproterenol-Treated African Green Monkeys
We have used filter-aided sample preparation (FASP) and tandem mass tag (TMT) labeling to investigate serum protein alterations in isoproterenol-treated African green monkeys.
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Almorexant Promotes Sleep and Exacerbates Cataplexy in a Murine Model of Narcolepsy
The current study was designed to evaluate the hypnotic and cataplexy-inducing efficacy of a Hcrt antagonist in an animal model with low Hcrt tone and compare the ALM efficacy profile…
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Computing Minimal Nutrient Sets from Metabolic Networks Via Linear Constraint Solving
We present a method for computationally determining alternative growth media for an organism based on its metabolic network and transporter complement.
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TB Mobile: A Mobile App for Anti-Tuberculosis Molecules with Known Targets
In order to learn from prior work we have collated information on molecules screened versus Mtb and their targets which has been made available in the Collaborative Drug Discovery (CDD) database.
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Proteolytic Enzymes as Biomarkers of Focal Segmental Glomerulosclerosis
Here, the library was utilized to map the global proteolytic specificities of plasma samples obtained from patients with the nephrotic syndrome, known as focal segmental glomerulosclerosis (FSGS).
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β-Carotene Biosynthesis in Probiotic Bacteria
To increase vitamin A coverage in malnourished children, we propose to engineer a probiotic bacterium that will produce β-carotene in the intestine, which will be metabolized to vitamin A.
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Anti-Oligomannose Antibodies as Potential Serum Biomarkers of Aggressive Prostate Cancer
This study bridges a carbohydrate microarray discovery and a large-scale serological validation of anti-oligomannose antibodies as novel serum biomarkers of aggressive prostate cancer.
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The Nicotine-Mediated Decline in L-Dopa-Induced Dyskinesias Is Associated with a Decrease in Striatal Dopamine Release
This study investigates whether nicotine may exert its beneficial effects by modulating pre-synaptic dopaminergic function.