Biomedical sciences publications
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Serum Biomarkers Reveal Long-Term Cardiac Injury in Isoproterenol-Treated African Green Monkeys
We have used filter-aided sample preparation (FASP) and tandem mass tag (TMT) labeling to investigate serum protein alterations in isoproterenol-treated African green monkeys.
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Almorexant Promotes Sleep and Exacerbates Cataplexy in a Murine Model of Narcolepsy
The current study was designed to evaluate the hypnotic and cataplexy-inducing efficacy of a Hcrt antagonist in an animal model with low Hcrt tone and compare the ALM efficacy profile…
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Computing Minimal Nutrient Sets from Metabolic Networks Via Linear Constraint Solving
We present a method for computationally determining alternative growth media for an organism based on its metabolic network and transporter complement.
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TB Mobile: A Mobile App for Anti-Tuberculosis Molecules with Known Targets
In order to learn from prior work we have collated information on molecules screened versus Mtb and their targets which has been made available in the Collaborative Drug Discovery (CDD) database.
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Immunoregulatory Profile of Monocytes from Cutaneous Leishmaniasis Patients and Association with Lesion Size
We evaluated peripheral blood CD14+ monocytes for the expression of immunoregulatory cytokines, co-stimulatory molecules and TLR9 from cutaneous leishmaniasis patients infected with L. braziliensis and noninfected individuals.
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The Twin Research Registry at SRI International
Twins in the TRR have participated in studies of complex, clinically relevant phenotypes that would not be feasible to measure in larger samples.
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Nighttime Cardiac Sympathetic Hyper-Activation in Young Primary Insomniacs
Impedance cardiography and heart rate variability (HRV) measures were assessed in 9 insomniacs and 9 good sleepers during a night of polysomnographic recording.
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Pharmacogenetic Smoking Cessation Intervention in a Health Care Setting: A Pilot Feasibility Study
We conducted a multiphased, mixed-methods feasibility study with current smokers to develop and evaluate a patient-centered, theoretically grounded personalized medicine treatment protocol.
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Are Women Who Smoke at Higher Risk for Lung Cancer Than Men Who Smoke?
We tested sex-smoking interaction in association with lung cancer risk within a population-based case-control study, the Environment and Genetics in Lung Cancer Etiology (EAGLE) Study (Lombardy, Italy, 2002–2005).
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Evaluation of IL17A Expression and of IL17A, IL17F and IL23R Gene Polymorphisms in Brazilian Individuals with Periodontitis
The aim of present study was to evaluate the expression of IL17A and occurrence of the IL17A (rs2275913), IL17F (rs763780) and IL23R (rs11209026) gene polymorphisms in different clinical forms or…
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Circadian Rhythm Disorders: Does Sex Matter?
There are sex-related differences in circadian rhythms with women having shorter intrinsic periods and earlier phase of both temperature and melatonin rhythms relative to men.
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Sex Differences in Sleep
There are sex differences in sleep behavior with women reporting more sleep problems and a poorer sleep quality than men across a wide age range.