Biomedical sciences publications
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Midbrain-Driven Emotion and Reward Processing in Alcoholism
Enhanced midbrain activation to alcohol-related words suggests neuroadaptation of dopaminergic midbrain systems. We speculate that such tuning is normally associated with behavioral conditioning to optimize responses but here contributed to…
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Pharmacological Characterization of GPR120 Ligands
The goal of the current study was to understand GPR120 ligand selectivity by testing agonist activity of various fatty acids in cell based assays to measure G-protein activated second messengers,…
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SR16388 Impairs Protein Homeostasis and Induces Autophagy in Diverse Human Cancer Cell Lines
SR16388 is a novel amino steroid that targets estrogen-binding proteins including genomic estrogen receptors.
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Genetic Analysis of a Population Heavy Drinking Phenotype Identifies Risk Variants in Whites
This proof-of-concept analysis examined whether population data of lifetime heaviest alcohol consumption may be used to identify genetic loci that modulate risk.
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In Vivo Glutamate Measured with Magnetic Resonance Spectroscopy: Behavioral Correlates in Aging
To investigate the contribution of regional glutamate levels to behavior in the aging brain, we used an in vivo magnetic resonance spectroscopy protocol optimized for glutamate detection in 3 brain regions targeted by…
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Development of Functional Assays for p97/VCP Inhibition
We used p97 siRNA and a recently identified small molecule p97 inhibitor, N2,N4-dibenzylquinazoline- 2,4-diamine (DBeQ) as tools to develop functional assays suitable for further evaluating the activity of potential p97…
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The Ability of Plasma Cotinine to Predict Nicotine and Carcinogen Exposure Is Altered by Differences in CYP2A6: The Influence of Genetics, Race, and Sex
Cotinine, a nicotine metabolite, is a biomarker of tobacco, nicotine, and carcinogen exposure. However, a given cotinine level may not represent the same tobacco exposure; for example, African-Americans have higher…
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Assessment of Cardiac Biomarkers in Cynomolgus Macaques
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Serum Biomarkers Reveal Long-Term Cardiac Injury in Isoproterenol-Treated African Green Monkeys
We have used filter-aided sample preparation (FASP) and tandem mass tag (TMT) labeling to investigate serum protein alterations in isoproterenol-treated African green monkeys.
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Almorexant Promotes Sleep and Exacerbates Cataplexy in a Murine Model of Narcolepsy
The current study was designed to evaluate the hypnotic and cataplexy-inducing efficacy of a Hcrt antagonist in an animal model with low Hcrt tone and compare the ALM efficacy profile…
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Computing Minimal Nutrient Sets from Metabolic Networks Via Linear Constraint Solving
We present a method for computationally determining alternative growth media for an organism based on its metabolic network and transporter complement.
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TB Mobile: A Mobile App for Anti-Tuberculosis Molecules with Known Targets
In order to learn from prior work we have collated information on molecules screened versus Mtb and their targets which has been made available in the Collaborative Drug Discovery (CDD) database.