Biomedical sciences publications
-
Highly Conserved CDR3 Region in Circulating CD4(+)V Beta 5(+) T Cells may be Associated with Cytotoxic Activity in Chagas Disease
The aim of this work was to determine whether T cells expressing this particular Vβ region displayed variable or restricted CDR3 sequences, as an indicator of the nature of the…
-
Genotoxicity of the Cancer Chemopreventive Drug Candidates CP-31398, SHetA2, and Phospho-Ibuprofen
The genotoxic activities of three cancer chemopreventive drug candidates, CP-31398 (a cell permeable styrylquinazoline p53 modulator), SHetA2 (a flexible heteroarotinoid), and phospho-ibuprofen (PI, a derivative of ibuprofen) were tested.
-
Quantification of Glutamate and Glutamine Using Constant-Time Point-Resolved Spectroscopy at 3 T
To quantify Glu and Gln, a time-domain basis set was constructed taking into account metabolite T 2 relaxation times and dephasing from B 0 inhomogeneity.
-
Aversive and Reinforcing Opioid Effects: A Pharmacogenomic Twin Study
Gaining a better understanding of the genetic and environmental mechanisms contributing to an individual's susceptibility to adverse opioid effects is essential to identify patients at risk.
-
Rodent Motor and Neuropsychological Behaviour Measured in Home Cages Using the Integrated Modular Platform SmartCage ™
To facilitate investigation of diverse rodent behaviours in rodents’ home cages, we have developed an integrated modular platform, the SmartCage™ system (AfaSci, Inc. Burlingame, CA, USA), which enables automated neurobehavioural phenotypic…
-
Two SHIPs Passing in the Middle of the Immune System
Using conditional knockouts of SHIP1 in either the myeloid or T-cell-lineage of mice, the authors show that the regulated development of Treg cells is controlled directly by cell-intrinsic SHIP1, and…
-
Cannabinoid Receptor Activation Correlates with the Proapoptotic Action of the beta(2)-Adrenergic Agonist (R,R ‘)-4-Methoxy-1-Naphthylfenoterol in HepG2 Hepatocarcinoma Cells
We compare the effect of the β2-AR agonists (R,R′)-fenoterol (Fen) and (R,R′)-4-methoxy-1-naphthylfenoterol (MNF) on signaling and cell proliferation in HepG2 hepatocarcinoma cells by using Western blotting and [3H]thymidine incorporation assays.
-
Anterograde Episodic Memory in Korsakoff Syndrome
In this review we highlight the historical studies that examined anterograde episodic memory processes in KS, present a timeline and evidence supporting the myriad theories proffered to account for this…
-
The Stereoselective Sulfate Conjugation of 4′-Methoxyfenoterol Stereoisomers by Sulfotransferase Enzymes
The presystemic sulfate conjugation of the stereoisomers of 4′-methoxyfenoterol, (R,R′)-MF, (S,S′)-MF, (R,S′)-MF, and (S,R′)-MF, was investigated using commercially available human intestinal S9 fractions, a mixture of sulfotransferase (SULT) enzymes.
-
Alphaviruses: Population Genetics and Determinants of Emergence
This review discusses the ecology, epidemiology and molecular virology of the alphaviruses, then focuses on three of the most important members of the genus.
-
Cortical nNOS Neurons Co-Express the NK1 Receptor and are Depolarized by Substance P in Multiple Mammalian Species
To evaluate the degree of co-expression of nNOS and NK1 in the cortex among mammals, we used double immunofluorescence for nNOS and NK1 and determined the anatomical distribution in mouse,…
-
Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics
Here we report on the identification and characterization of the first selective and potent TAAR1 partial agonist.