Biomedical sciences publications

The present study tested the hypothesis that the amplitude of K-complex related evoked potential components would increase with prolonged abstinence from alcohol.

We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydrolysis of organophosphate (OP)-inhibited hAChE in the CNS.

The present study seeks to resolve some of these issues in a combined cross-sectional and longitudinal analysis of sleep EEG in adolescents.

Here we demonstrate biological activity for two peptides present within proNPQ/spexin. NPQ/spexin and NPQ 53–70 have differing renal and cardiovascular effects when administered intracerebroventricularly or intravenously into rats.

The introduction of forward genetics has provided novel means to gain a better understanding of gene functions and their associated phenotypes in Plasmodium.

On the basis of hemopressin’s potential in therapeutic applications and the lack of a structure–activity relationship study in literature, we aimed to determine the conformational features of hemopressin under physiological…

We use recently-developed Quantitative Susceptibility Mapping (QSM) methodology to estimate the tissue magnetic susceptibility based on MRI signal phase.

In order to better examine this receptor subtype, we have identified and characterized the first high affinity and selective α3β4 nAChR antagonist, AT-1001, both in vitro and in vivo.

We tested whether previously published functional magnetic resonance imaging data acquired in 15 recovering alcoholics and 15 controls at rest and while performing a spatial working memory task would fulfill…

Factors that contribute to the formation of SP turns include controlling backbone flexibility and amino acid chirality along with creating a hydrophobic environment around the intramolecular hydrogen bonds.

The purpose of this study was to assess whether cytochrome P450 enzyme 2A6 (CYP2A6) genotypes moderate the association between smoking and hypertension.

We have approached this question by analyzing the effect of mammalian target of rapamycin (mTOR), a central growth controller, on the osmotic stress response.