Biomedical sciences publications
-
Effect of Fenoterol Stereochemistry on the β2 Adrenergic Receptor System: Ligand-Directed Chiral Recognition
The β2 adrenergic receptor (β2-AR) is a model system for studying the ligand recognition process in G protein-coupled receptors. Fenoterol (FEN) is a β2-AR selective agonist that has two centers of…
-
Nicotinic Receptor Agonists Decrease L-Dopa-Induced Dyskinesias Most Effectively in Partially Lesioned Parkinsonian Rats
To further understand how nicotine mediates its antidyskinetic action, we investigated the effect of nicotinic receptor (nAChR) agonists in unilateral 6-OHDA-lesioned rats with varying striatal damage.
-
Associations of Cyp2A6 Genotype with Smoking Behaviors in Southern China
-
Application of Double Spin Echo Spiral Chemical Shift Imaging to Rapid Metabolic Mapping of Hyperpolarized [1 – 13C]-Pyruvate
This work extends the spCSI sequence by incorporating double spin-echo radiofrequency (RF) pulses to eliminate the need for phase correction and obtain high quality spectra in magnitude mode.
-
Systems Level in Silico Pathway Analysis Predicts Metabolites That Are Potential Antimicrobial Targets
-
Identification of Antimicrobial Activity Among FDA-Approved Drugs for Combating Mycobacterium Abscessus and Mycobacterium Chelonae
The purpose of this work is to identify new candidate drugs for treating non-tuberculous mycobacteria (NTM) by testing FDA-approved drugs for antimicrobial activity.
-
A Platform for the Detection of Trypanosomes Via Selective Small Molecule Recognition
Trypanothione (TSH2), a metabolite unique to trypanosomal parasites, was evaluated as a potential biomarker for trypanosomal infection using fluorescence as the means of detection.
-
A Melanoma Molecular Disease Model
This paper describes such a Melanoma Molecular Disease Model reflecting the latest scientific, clinical, and technological advances.
-
Disruption of Functional Connectivity of the Default-Mode Network in Alcoholism
We examined DMN functional connectivity using functional magnetic resonance imaging (fMRI) data and graph theory analysis.
-
Competition Between Intradomain and Interdomain Interactions: a Buried Salt Bridge Is Essential for Villin Headpiece Folding and Actin Binding
We used mutational analysis, monitored by CD and NMR, and functional assays to determine the role of this buried salt bridge.
-
Sensitivity to Secondhand Smoke Exposure Predicts Smoking Susceptibility in 8-13-Year-Old Never Smokers
We assessed the sensitivity to SHSe using reactions commonly used for the assessment of sensitivity to the first-smoked cigarette, and investigated the factor structure of these reactions for the purpose…
-
The Growth Factor Progranulin Binds to Tnf Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice
We report that PGRN bound directly to tumor necrosis factor receptors (TNFRs) and disturbed the TNFα-TNFR interaction. PGRN-deficient mice were susceptible to collagen-induced arthritis, and administration of PGRN reversed inflammatory…