Biomedical sciences publications
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Disruption of Emotion and Conflict Processing in HIV Infection with and Without Alcoholism Comorbidity
We investigated whether patients with alcoholism, HIV-1 infection, or both diseases have greater difficulty than healthy controls in resolving conflict from emotional words with different valences.
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Acylideneoxoindoles: A New Class of Reversible Inhibitors of Human Transglutaminase 2
Inhibitors of human transglutaminase 2 (TG2) are anticipated to be useful in the therapy of a variety of diseases including celiac sprue as well as certain CNS disorders and cancers.
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Identification of Antimicrobial Activity Among FDA-Approved Drugs for Combating Mycobacterium Abscessus and Mycobacterium Chelonae
The purpose of this work is to identify new candidate drugs for treating non-tuberculous mycobacteria (NTM) by testing FDA-approved drugs for antimicrobial activity.
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A Platform for the Detection of Trypanosomes Via Selective Small Molecule Recognition
Trypanothione (TSH2), a metabolite unique to trypanosomal parasites, was evaluated as a potential biomarker for trypanosomal infection using fluorescence as the means of detection.
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Associations of Cyp2A6 Genotype with Smoking Behaviors in Southern China
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Application of Double Spin Echo Spiral Chemical Shift Imaging to Rapid Metabolic Mapping of Hyperpolarized [1 – 13C]-Pyruvate
This work extends the spCSI sequence by incorporating double spin-echo radiofrequency (RF) pulses to eliminate the need for phase correction and obtain high quality spectra in magnitude mode.
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Systems Level in Silico Pathway Analysis Predicts Metabolites That Are Potential Antimicrobial Targets
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Competition Between Intradomain and Interdomain Interactions: a Buried Salt Bridge Is Essential for Villin Headpiece Folding and Actin Binding
We used mutational analysis, monitored by CD and NMR, and functional assays to determine the role of this buried salt bridge.
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Sensitivity to Secondhand Smoke Exposure Predicts Smoking Susceptibility in 8-13-Year-Old Never Smokers
We assessed the sensitivity to SHSe using reactions commonly used for the assessment of sensitivity to the first-smoked cigarette, and investigated the factor structure of these reactions for the purpose…
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The Growth Factor Progranulin Binds to Tnf Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice
We report that PGRN bound directly to tumor necrosis factor receptors (TNFRs) and disturbed the TNFα-TNFR interaction. PGRN-deficient mice were susceptible to collagen-induced arthritis, and administration of PGRN reversed inflammatory…
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Direct inhibition of hypocretin/orexin neurons in the lateral hypothalamus by nociceptin/orphanin FQ blocks stress-induced analgesia in rats
We tested the hypothesis that N/OFQ modulates the SIA directly via the inhibition of the Hcrt neurons in the lateral hypothalamus.
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Sleep and the Brain
This issue’s special section on “Sleep through the Ages” contains papers addressing the neurological and neuropsychological implications of sleep in adolescents, older adults and insomnia sufferers, highlighting relations of sleep…