Biomedical sciences publications
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Pontocerebellar Contribution to Postural Instability and Psychomotor Slowing in HIV Infection Without Dementia
We examined whether infratentorial brain tissue volume would be deficient in nondemented HIV-infected individuals and whether selective tissue deficits would be related to postural stability and psychomotor speed performance.
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SR16388: a Steroidal Antiangiogenic Agent with Potent Inhibitory Effecton Tumor Growth in Vivo
We have developed a novel class of steroidal compounds aimed at blocking the angiogenic process in cancerous tissues.
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Association of the Calcyon Neuron-Specific Vesicular Protein Gene (Caly) with Adolescent Smoking Initiation in China and California
These results suggest that the CALY gene may influence smoking initiation in adolescents, although the potential roles of underlying psychological characteristics remain to be explored.
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Changes in Sleep as a Function of Adolescent Development
While changes in sleep across adolescence are a normal part of development, many adolescents are getting insufficient sleep and are consequently, less likely to perform well at school, more likely…
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Nonprofit Organizations and Pharmaceutical Research and Development
To provide a perspective on NPO business models, 10 SRI case studies spanning a broad range of technical and business initiatives are summarized herein, including basic and contract research, discovery…
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Association of the Nicotine Metabolite Ratio and CHRNA5/CHRNA3 Polymorphisms with Smoking Rate Among Treatment-Seeking Smokers
Genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in the CHRNA5/A3/B4 gene cluster with heaviness of smoking.
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Phase 0 Clinical Chemoprevention Trial of the Akt Inhibitor Sr13668
We designed and conducted the first-ever phase 0 chemoprevention trial to evaluate and compare the effects of food and formulation on SR13668 bioavailability.
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A Melanoma Molecular Disease Model
This paper describes such a Melanoma Molecular Disease Model reflecting the latest scientific, clinical, and technological advances.
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Disruption of Functional Connectivity of the Default-Mode Network in Alcoholism
We examined DMN functional connectivity using functional magnetic resonance imaging (fMRI) data and graph theory analysis.
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In-Vivo Imaging of Femoral Artery Nitinol Stents for Deformation Analysis
The authors have developed a direct method to study femoral artery stent deformations in vivo.
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A Study of Barrier Walls for Mitigation of Unintended Releases of Hydrogen
An experimental and modeling program has been performed at Sandia National Laboratories to better characterize the effectiveness of barrier walls to reduce hazards. This paper describes the experimental and modeling…
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Beta(2)-Adrenergic Receptor Agonists Inhibit the Proliferation of 1321N1 Astrocytoma Cells
Experiments were conducted to determine whether the β2-AR agonist (R,R′)-fenoterol and other β2-AR agonists could attenuate mitogenesis and, if so, by what mechanism.