Biomedical sciences publications
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Direct inhibition of hypocretin/orexin neurons in the lateral hypothalamus by nociceptin/orphanin FQ blocks stress-induced analgesia in rats
We tested the hypothesis that N/OFQ modulates the SIA directly via the inhibition of the Hcrt neurons in the lateral hypothalamus.
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Sleep and the Brain
This issue’s special section on “Sleep through the Ages” contains papers addressing the neurological and neuropsychological implications of sleep in adolescents, older adults and insomnia sufferers, highlighting relations of sleep…
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Pontocerebellar Contribution to Postural Instability and Psychomotor Slowing in HIV Infection Without Dementia
We examined whether infratentorial brain tissue volume would be deficient in nondemented HIV-infected individuals and whether selective tissue deficits would be related to postural stability and psychomotor speed performance.
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SR16388: a Steroidal Antiangiogenic Agent with Potent Inhibitory Effecton Tumor Growth in Vivo
We have developed a novel class of steroidal compounds aimed at blocking the angiogenic process in cancerous tissues.
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Association of the Calcyon Neuron-Specific Vesicular Protein Gene (Caly) with Adolescent Smoking Initiation in China and California
These results suggest that the CALY gene may influence smoking initiation in adolescents, although the potential roles of underlying psychological characteristics remain to be explored.
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Changes in Sleep as a Function of Adolescent Development
While changes in sleep across adolescence are a normal part of development, many adolescents are getting insufficient sleep and are consequently, less likely to perform well at school, more likely…
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Nonprofit Organizations and Pharmaceutical Research and Development
To provide a perspective on NPO business models, 10 SRI case studies spanning a broad range of technical and business initiatives are summarized herein, including basic and contract research, discovery…
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Association of the Nicotine Metabolite Ratio and CHRNA5/CHRNA3 Polymorphisms with Smoking Rate Among Treatment-Seeking Smokers
Genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in the CHRNA5/A3/B4 gene cluster with heaviness of smoking.
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Phase 0 Clinical Chemoprevention Trial of the Akt Inhibitor Sr13668
We designed and conducted the first-ever phase 0 chemoprevention trial to evaluate and compare the effects of food and formulation on SR13668 bioavailability.
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Antibody Response to Polyhistidine-Tagged Peptide and Protein Antigens Attached to Liposomes Via Lipid-Linked Nitrilotriacetic Acid in Mice
We evaluate noncovalent metal chelation via nitrilotriacetic acid (NTA) as a nondestructive method to attach peptide and protein antigens to liposomes.
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Evaluation of Acute Locoregional Toxicity in Patients with Breast Cancer Treated with Adjuvant Radiotherapy in Combination with Bevacizumab
The purpose of this study was to analyze acute locoregional toxicity in patients with breast cancer receiving concurrent bevacizumab plus RT.
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Cortical Aspects of Breathing Control and Sensation: a Comment on Von Leupoldt Et Al. (2010), “Cortical Sources of the Respiratory-Related Evoked Potential”