Biomedical sciences publications
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A High-Throughput Fluorescence Polarization Assay for Inhibitors of Gyrase B
The assay performed with an average Z′ factor of 0.80 and was able to identify GyrB inhibitors from a screening library.
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Relationship Between Circulating Platelet Counts and Ductus Arteriosus Patency After Indomethacin Treatment
In contrast to the evidence in mice, low circulating platelet counts do not affect permanent ductus closure (or ductus reopening) in human preterm infants.
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Functional and Anatomical Remapping of Corticocerebellar Loops in Alcoholism
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Independent Contributions of Cortical Gray Matter, Aging, Sex and Alcoholism to K-Complex Amplitude Evoked During Sleep
The amplitude of the N550 component derived from the averaged evoked K-complex decreases with normal aging and with alcoholism. The study was designed to determine whether these declines are related…
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Recommendations for the Validation of Flow Cytometric Testing During Drug Development: I Instrumentation
This paper presents a consensus methodological approach that the authors have used successfully to ensure data integrity in flow cytometric studies conducted during drug development.
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Functional and Structural Connectivity and Executive Control in Chronic Alcoholism: a Combined DTI and fMRI Study
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Neurological assessments after treatment with the antimalarial beta-arteether in neonatal and adult rats
This study shows that repeated treatment with clinically relevant doses of βAE causes motor deficits associated with brainstem damage in rodents and suggests that repeated treatment with βAE in children…
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Partial Occupancy of the Glycine Transporter Type 1 in Monkey By Rg1678 Leads to Efficacy in a Model of Prefrontal Cortical Function
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Pharm GKB Summary: Dopamine Receptor D2
Dopamine is a catecholamine neurotransmitter and controls a variety of functions including cognition, emotion, locomotor activity, food intake, and endocrine system regulation in the central nervous system.
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Universal Opioid Receptor Ligands – Buprenorphine and Related Orvinols
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Electrophysiological Evidence of Enhanced Performance Monitoring in Recently Abstinent Alcoholic Men
The objective of this paper is to identify electrophysiological mechanisms of such compensation that would be required to resolve response conflict.
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Neuropeptide B Induces Slow Wave Sleep in Mice
These results suggest that NPB induced physiological SWS through GPR7 and that NPB and GPR7 may have a role in modulating the occurrence of sleep and wakefulness.