Biomedical sciences publications
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Discovery of 1-[3-(4-Bromo-2-Methyl-2H-Pyrazol-3-Yl)-4-Methoxyphenyl]-3-(2, 4-Difluorophenyl)Urea (Nelotanserin) and Related 5-Hydroxytryptamine 2A Inverse Agonists for the Treatment of Insomnia
We describe here a series of 5-HT2A inverse-agonists that when dosed in rats, both consolidate the stages of NREM sleep, resulting in fewer awakenings, and increase a physiological measure of sleep…
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The Use of Orthologous Sequences to Predict the Impact of Amino Acid Substitutions on Protein Function
We examined this assumption by evaluating a panel of nonsynonymous mutants of a prototypical human enzyme, methylenetetrahydrofolate reductase (MTHFR), in a yeast cell-based functional assay.
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Folate Receptor Targeted Nanophosphors for Enhanced Tumor Radiotherapy
Here we present a folic acid (FA) conjugated nanophosphor (NP) intended to enhance the therapeutic effect of radiotherapy by augmenting the production of reactive oxygen species with simultaneous photodynamic therapy…
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Using DNA Fingerprints to Infer Familial Relationships Within NHANES III Households
We inferred family relationships within households using DNA fingerprints (Identifiler®) that contain the DNA loci used by law enforcement agencies for forensic identification of individuals.
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Compensatory Anterior Frontal Slow Wave Activity in Recently Sober Alcoholic Men
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Reduced Prefrontal Responsiveness to Alcohol Stimuli in Chronic Alcoholism
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Comparative Molecular Field Analysis of Fenoterol Derivatives: a Platform Towards Highly Selective and Effective Beta(2)-Adrenergic Receptor Agonists
We use a previously developed CoMFA model to design a series of new structures of high selectivity and efficacy towards the β2-adrenergic receptor.
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Lysosomal Degradation of Alpha-Synuclein in Vivo
In this study, lysosomal clearance of α-synuclein in vivo was indicated by the detection of α-synuclein in the lumen of lysosomes isolated from the mouse midbrain.
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SU11248 (Sunitinib) Directly Inhibits the Activity of Mammalian 5′-AMP-Activated Protein Kinase (AMPK)
Here we report that the chemotherapeutic drug SU11248 (sunitinib) is at least as potent an inhibitor of AMPK as compound C, which is a commonly used experimental direct inhibitor of…
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Comprehensive Evaluation of Let-Dependence of Chromosome Aberrations After Particle Radiation Exposure in Vivo
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Distinguishing Methicillin-Resistant and Sensitive Staphylococcus Aureus Using Volatile Headspace Metabolites
This proof-of-concept study used solid-phase microextraction fibers (SPME) to collect headspace vapors from a methicillin sensitive Staphylococcus aureus (MSSA) and a methicillin-resistant Staphylococcus aureus (MRSA) strain grown in vitro in liquid growth medium.
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Alcohol’s Effects on Brain and Behavior
One main area of this research has focused on the neuropsychological sequelae of alcoholism, which has resulted in the description of a pattern of sparing and impairment that provided an…