Biomedical sciences publications

We describe here a series of 5-HT2A inverse-agonists that when dosed in rats, both consolidate the stages of NREM sleep, resulting in fewer awakenings, and increase a physiological measure of sleep…

Here we present a folic acid (FA) conjugated nanophosphor (NP) intended to enhance the therapeutic effect of radiotherapy by augmenting the production of reactive oxygen species with simultaneous photodynamic therapy…

We examined this assumption by evaluating a panel of nonsynonymous mutants of a prototypical human enzyme, methylenetetrahydrofolate reductase (MTHFR), in a yeast cell-based functional assay.

We inferred family relationships within households using DNA fingerprints (Identifiler®) that contain the DNA loci used by law enforcement agencies for forensic identification of individuals.

We use a previously developed CoMFA model to design a series of new structures of high selectivity and efficacy towards the β2-adrenergic receptor. 

In this study, lysosomal clearance of α-synuclein in vivo was indicated by the detection of α-synuclein in the lumen of lysosomes isolated from the mouse midbrain.

This proof-of-concept study used solid-phase microextraction fibers (SPME) to collect headspace vapors from a methicillin sensitive Staphylococcus aureus (MSSA) and a methicillin-resistant Staphylococcus aureus (MRSA) strain grown in vitro in liquid growth medium.

Here we report that the chemotherapeutic drug SU11248 (sunitinib) is at least as potent an inhibitor of AMPK as compound C, which is a commonly used experimental direct inhibitor of…

Three independent risk factors are associated with patent ductus arteriosus that fail to close during prostaglandin inhibition.