Biomedical sciences publications
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Decreased Alpha-Synuclein Expression in the Aging Mouse Substantia Nigra
Here we compared α-synuclein expression in the substantia nigra and other brain regions of young (2-month-old), middle-aged (10-month-old), and old (20-month-old) mice.
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Mechanisms of Postural Control in Alcoholic Men and Women: Biomechanical Analysis of Musculoskeletal Coordination During Quiet Standing
Whether alcoholic men and women who have remained abstinent from alcohol for weeks to months differ from each other in the degree of residual postural instability and biomechanical control mechanisms…
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Selective Deficiency of HIF-1 Alpha in Myeloid Cells Influences Secondary Intention Wound Healing in Mouse Skin
In this study we examined the role of myeloid cell HIF-1α on wound healing in vivo using a cell-specific knockout (KO) mouse model.
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Influence of Formulation Factors on Tablet Formulations with Liquid Permeation Enhancer Using Factorial Design
Factorial design was used to evaluate the effect of three formulation factors: drug percentage, polymer type, and tablet binder percentage on tablet characteristics.
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Formulation and in Vitro Characterization of Spray-Dried Antisense Oligonucleotide to Nf-B Encapsulated Albumin Microspheres
The aim of this study was to formulate and characterize microspheres containing antisense oligonucleotide to NF-κB using bovine serum albumin as the polymer matrix.
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Formulation and in Vitro Characterization of Spray-Dried Antisense Oligonucleotide to NF-Kappa B Encapsulated Albumin Microspheres
The aim of this study was to formulate and characterize microspheres containing antisense oligonucleotide to NF-κB using bovine serum albumin as the polymer matrix.
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Caffeine Elicits c-Fos Expression in Horizontal Diagonal Band Cholinergic Neurons
We determined the effects of caffeine on cholinergic neuron activation in the rat basal forebrain.
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SR16157 Is a Potent Dual-Acting Inhibitor of Estrogen Biosynthesis and Estrogen Receptor
Using in vitro and xenograft MCF-7 breast cancer models, we demonstrated that SR16157 inhibited STS activity, cell growth, and estrogenic functions and that SR16137 reduced expression of estrogen-regulated genes with greater potency…
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A Genome-Wide Association Study of Lung Cancer Identifies a Region of Chromosome 5P15 Associated with Risk for Adenocarcinoma
We conducted a GWAS of lung cancer and its major histologic types, genotyping 515,922 single-nucleotide polymorphisms (SNPs) in 5739 lung cancer cases and 5848 controls from one population-based case-control study…
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A Phase I Study of the Nitroimidazole Hypoxia Marker SR4554 Using 19 F Magnetic Resonance Spectroscopy
In this study we investigated higher doses of SR4554 and intratumoral localisation of the 19F MRS signal.
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Increased CCL2 Expression and Macrophage/Monocyte Migration During Microbicide-Induced Vaginal Irritation
We studied several immunological parameters as potential biomarkers of vaginal irritation, using the spermicides nonoxynol-9 and benzalkonium chloride as test microbicides.
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Double Dissociation Between Action-Driven and Perception-Driven Conflict Resolution Invoking Anterior Versus Posterior Brain Systems
We manipulated perceptual information that either matched or did not match the relevant color feature of an upcoming Stroop stimulus and recorded hemodynamic brain responses to these events.