Biomedical sciences publications
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A Phase I Study of the Nitroimidazole Hypoxia Marker SR4554 Using 19 F Magnetic Resonance Spectroscopy
In this study we investigated higher doses of SR4554 and intratumoral localisation of the 19F MRS signal.
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Increased CCL2 Expression and Macrophage/Monocyte Migration During Microbicide-Induced Vaginal Irritation
We studied several immunological parameters as potential biomarkers of vaginal irritation, using the spermicides nonoxynol-9 and benzalkonium chloride as test microbicides.
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Double Dissociation Between Action-Driven and Perception-Driven Conflict Resolution Invoking Anterior Versus Posterior Brain Systems
We manipulated perceptual information that either matched or did not match the relevant color feature of an upcoming Stroop stimulus and recorded hemodynamic brain responses to these events.
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Bright Lights, Clearly Visible in the Healthcare R&D Tunnel, Could Burn Out for Lack of Funds
The promise of continued healthcare innovation is increasingly threatened by inadequate funding of R&D at many levels: in academic and nonprofit organizations, in small business ventures, and even in large…
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Geo-Based Aerial Surveillance Video Processing for Scene Understanding and Object Tracking
This paper presents an approach to extract semantic layers from aerial surveillance videos for scene understanding and object tracking.
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In Vivo Glutamate Decline Associated with Kainic Acid-Induced Status Epilepticus
Here, we present data using in vivo magnetic resonance spectroscopy (MRS) optimized for the detection of glutamate to identify changes that evolve following kainic acid (KA)-induced status epilepticus.
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Effects of Ramelteon and Triazolam in a Mouse Genetic Model of Early Morning Awakenings
We test the hypothesis that timed daily administration of a melatonin agonist, ramelteon, or a benzodiazepine, triazolam, normalizes the timing of daily wheel-running rhythms in early runner mice.
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Magnetic Resonance Imaging of the Living Brain
Longitudinal MRI studies of animal models of alcoholism, however, can address questions about the development and course of alcohol dependence and the scope and limits of in vivo degeneration and…
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Genetic Influences on Individual Differences in Nicotine Glucuronidation
Nicotine and its primary oxidative metabolites are metabolized in part by glucuronidation. Genetic variation in UGT isoenzymes that catalyze glucuronidation activity suggests that variation in glucuronidation rate is in part…
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Clinical Trial Participant Characteristics and Saliva and DNA Metrics
This article describes an assessment of saliva biospecimen samples collected through the mail, trial participant demographic and behavioral characteristics, and their association with saliva and DNA quantity and quality.
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Oxygen-Induced Tension in the Sheep Ductus Arteriosus: Effects of Gestationon Potassium and Calcium Channel Regulation
We used isolated fetal sheep ductus arteriosus (pretreated with inhibitors of prostaglandin and nitric oxide production) to determine whether changes in K+- and CaL-channel activity could account for the developmental…
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Protein Expression Is Altered During Spontaneous Sleep in Aged Sprague Dawley Rats
Age-related changes in brain function include those affecting learning, memory, and sleep-wakefulness. Sleep-wakefulness is an essential behavior that results from the interaction of multiple brain regions, peptides, and neurotransmitters.