Biomedical sciences publications
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Effects of Ramelteon and Triazolam in a Mouse Genetic Model of Early Morning Awakenings
We test the hypothesis that timed daily administration of a melatonin agonist, ramelteon, or a benzodiazepine, triazolam, normalizes the timing of daily wheel-running rhythms in early runner mice.
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Genetic Influences on Individual Differences in Nicotine Glucuronidation
Nicotine and its primary oxidative metabolites are metabolized in part by glucuronidation. Genetic variation in UGT isoenzymes that catalyze glucuronidation activity suggests that variation in glucuronidation rate is in part…
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Clinical Trial Participant Characteristics and Saliva and DNA Metrics
This article describes an assessment of saliva biospecimen samples collected through the mail, trial participant demographic and behavioral characteristics, and their association with saliva and DNA quantity and quality.
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Frontostriatal Fiber Bundle Compromise in HIV Infection Without Dementia
Quantitative fiber tracking derived from diffusion tensor imaging (DTI) was used to determine whether white matter association, projection, or commissural tracts are affected in nondemented individuals with HIV infection and to identify…
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Physiological and Focal Cerebellar Substrates of Abnormal Postural Sway and Tremor in Alcoholic Women
Sway and tremor abnormalities and the selective relations between greater sway and 5 Hz to 7 Hz tremor and smaller volumes of the anterior vermis had not heretofore been described…
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Comparison of the Antinociceptive and Antirewarding Profiles of Novel Bifunctional Nociceptin Receptor/Mu-Opioid Receptor Ligands: Implications for Therapeutic Applications
We hypothesized that NOPr agonists, with bifunctional activity at the μ-opioid receptor (MOPr), may function as nonaddicting analgesics or as drug abuse medications.
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The Wake-Promoting Effects of Hypocretin-1 are Attenuated in Old Rats
We sought to determine whether the wake-promoting effect of hypocretin changes with age in Wistar rats, a strain in which age-related changes in both sleep and hypocretin signaling have been…
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Pharmacokinetics and Enhanced Bioavailability of Candidate Cancer Preventative Agent, SR13668 in Dogs and Monkeys
SR13668 showed promising anti-cancer activity, however, it exhibited a very poor oral bioavailability. Therefore, a study was initiated to develop and evaluate formulations with a more favorable oral bioavailability.
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Nonprofit Organizations and Pharmaceutical Research and Development
To provide a perspective on NPO business models, 10 SRI case studies are summarized herein, including basic and contract research, discovery of new drugs and biologics, pharmaceutical and biotech R&D…
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Gene and Gene By Sex Associations with Initial Sensitivity to Nicotine in Nonsmokers
This study explored associations of functional candidate gene polymorphisms with initial sensitivity to nicotine in 101 young adult nonsmokers of European ancestry.
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Visualizing Implanted Tumors in Mice with Magnetic Resonance Imaging Using Magnetotactic Bacteria
Magnetotactic bacteria can produce positive magnetic resonance imaging contrast and colonize mouse tumor xenografts, providing a potential tool for improved magnetic resonance imaging visualization in preclinical and translational studies to…
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MRI Estimates of Brain Iron Concentration in Normal Aging: Comparison of Field-Dependent (Fdri) and Phase (Swi) Methods
The results showed that both methods detected high globus pallidus iron concentration regardless of age and significantly greater iron in putamen with advancing age.