Biomedical sciences publications
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Variants in Nicotinic Receptors and Risk for Nicotine Dependence
The purpose of this study was to replicate these findings in an independent data set and more thoroughly investigate the role of genetic variation in the cluster of physically linked…
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Special Issue on Video Surveillance Research in Industry and Academia
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Mast Cell-Expressed Orphan Receptor Ccrl2 Binds Chemerin and Is Required for Optimal Induction of Ige-Mediated Passive Cutaneous Anaphylaxis
We show that the mast cell–expressed orphan serpentine receptor mCCRL2 is not required for expression of IgE-mediated mast cell–dependent passive cutaneous anaphylaxis but can enhance the tissue swelling and leukocyte…
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Comparison of Filling Agents for Lip Augmentation
The authors discuss various filling agents currently available that can be used to augment the lips, correct perioral rhytides, and enhance overall lip appearance.
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The Influence of Reproductive Status and Age on Women’s Sleep
This review paper summarizes presentations from a conference update on the state of knowledge about the extent to which reproductive status and age influence women's sleep.
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Gene Expression Analysis Reveals New Possible Mechanism of Vancomycin-Induced Nephrotoxicity and Identifies Gene Markers Candidates
The goals of this study were to gain insights into molecular mechanisms of nephrotoxicity at the genomic level, evaluate gene markers of vancomycin-induced kidney injury, and compare gene expression responses…
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Genome-Wide Linkage of Cotinine Pharmacokinetics Suggests Candidate Regionson Chromosomes 9 and 11
We conducted a whole-genome linkage analysis to search for candidate regions influencing quantitative variation in cotinine pharmacokinetics in a large-scale pharmacokinetic study with 61 families containing 224 healthy adult participants.
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Translational Studies of Alcoholism: Bridging the Gap
Together, studies in humans and animal models have provided support for the involvement of specific brain structures over the course of alcohol addiction.
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Detoxification of Molinate Sulfoxide: Comparison of Spontaneous and Enzmatic Glutathione Conjugation Using Human and Rat Liver Cytosol
This study compared the metabolic capability of rat and human liver cytosol to form a glutathione (GSH)-conjugated metabolite of molinate.
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17 Alpha-Estradiol: a Less-Feminizing Estrogen
A substantial number of studies report that 17β-estradiol (E2; estrogen), a potent endogenous feminizing hormone, is neuroprotective.
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In Vivo Evidence for Alcohol-Induced Neurochemical Changes in Rat Brain Without Protracted Withdrawal, Pronounced Thiamine Deficiency, or Severe Liver Damage
Longitudinal effects of alcohol on brain metabolites measured in basal ganglia with single-voxel MRS were investigated in sibling pairs of wild-type Wistar rats, with one rat per pair exposed to…
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Adamantyl-Substituted Retinoid-Derived Molecules That Interact with the Orphan Nuclear Receptor Small Heterodimer Partner: Effects of Replacing the 1-Adamantyl or Hydroxyl Groupon Inhibition of Cancer Cell Growth, Induction of Cancer Cell Apoptosis, and Inhibition of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2 Activity
Abstract (E)-4-[3-(1-Adamantyl)-4′-hydroxyphenyl]-3-chlorocinnamic acid (3-Cl-AHPC) induces the cell-cycle arrest and apoptosis of leukemia and cancer cells. Studies demonstrated that 3-Cl-AHPC bound to the atypical orphan nuclear receptor small heterodimer partner (SHP).…