Biomedical sciences publications
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Comparing Two Strains of Rats in the Chronic Construction Injury Model of Neuropathic Pain
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Genetic Influences in the Variation in Renal Clearance of Nicotine and Cotinine
In this study of 139 pairs of twins, we have estimated the genetic and environmental contributions to total renal clearance and net secretory/ reabsorptive clearance of nicotine and cotinine.
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Detoxification of Molinate Sulfoxide: Comparison of Spontaneous and Enzmatic Glutathione Conjugation Using Human and Rat Liver Cytosol
This study compared the metabolic capability of rat and human liver cytosol to form a glutathione (GSH)-conjugated metabolite of molinate.
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L-Selectin-Deficient SJL and C57Bl/6 Mice Are Not Resistant to Experimental Autoimmune Encephalomyelitis
L-selectin has been suggested to play a role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Here we demonstrate that L-selectin–/– SJL mice are susceptible…
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Neuroinflammation as a Neurotoxic Mechanism in Alcoholism: Commentaryon “Increased Mcp-1 and Microglia in Various Regions of Human Alcoholic Brain”
Neuropathological studies of chronic alcoholism indicate that loss of neurons is selective to frontal cortex (Courville, 1955, Harper and Kril, 1990) with little evidence for widespread cell loss (Harper, 1998,…
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Identification of a Population of Sleep-Active Cerebral Cortex Neurons
We have identified a population of cells in the cortex that is activated during sleep in three mammalian species. These cortical neurons are a subset of GABAergic interneurons that express…
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Reduced Parasympathetic Activity During Sleep in the Symptomatic Phase of Severe Premenstrual Syndrome
We investigated HRV during sleep, a state that is relatively free of external disruptions, in 9 women with severe PMS and 12 controls.
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Nutritional Stress Affects Mosquito Survival and Vector Competence for West Nile Virus
We evaluated the effect of different sucrose meals following a blood meal containing West Nile virus (WNV) on Culex pipiens pipiens survival, nutritional status, and susceptibility to viral infection and transmission.
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Cortical Processing of Respiratory Occlusion Stimuli in Children with Central Hypoventilation Syndrome
Cortical integration of afferent mechanical stimuli caused by respiratory loading or upper airway occlusion can be tested by measuring respiratory-related evoked potentials (RREPs). We hypothesized that patients with CHS would…
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Sleep Deprivation Effects on Circadian Clock Gene Expression in the Cerebral Cortex Parallel Electroencephalographic Differences Among Mouse Strains
Sleep deprivation (SD) results in increased electroencephalographic (EEG) delta power during subsequent non-rapid eye movement sleep (NREMS) and is associated with changes in the expression of circadian clock-related genes in…
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Ventricular Expansion After Alcohol Exposure By Vapor Chamber in Wistar Rats
Here, we tested the hypothesis that wild-type Wistar rats, exposed to vaporized alcohol ensuring higher BALs than typically achieved with voluntary consumption in rodents, would model MRI findings in the…
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Ventricular Expansion in Wild-Type Wistar Rats After Alcohol Exposure By Vapor Chamber
Here, we tested the hypothesis that wild-type Wistar rats, exposed to vaporized alcohol ensuring higher BALs than typically achieved with voluntary consumption in rodents, would model MRI findings in the…