Biomedical sciences publications
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Inspiratory Contrast for in Vivo Optical Imaging
We demonstrate the use of inspired oxygen and carbon dioxide as a possible route to increase contrast in optical imaging of cancerous tissue.
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The Impact of Smoking Cessation on Sleep
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Evoked Delta Activity During Sleep in Alcoholism
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Fe-Radiation-Induced Alterations in Circulating Leukocyte Populations in the Apoe Mouse Atherosclerosis Model Are Temporary
We irradiated ApoE mice with 56Fe focused to the aorta and carotids to determine how irradiation of the thymus with 56Fe affects circulating lymphocyte number, and ultimately to determine the…
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Genetics of Nicotine Dependence and Pharmacotherapy
Despite significant strides in the understanding of the relative contribution of genetic and environmental factors to nicotine dependence and treatment, emergent challenges necessitate interdisciplinary coordinated effort for effective problem solving
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Callosal Compromise Differentially Affects Conflict Processing and Attentional Allocation in Alcoholism, HIV, and Their Comorbidity
Diffusion tensor imaging was used to study the combined effects of HIV-infection and alcoholism (ALC) on corpus callosum (CC) integrity in relation to processes of attentional allocation and conflict resolution…
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Effects of Saporin-Induced Lesions of Three Arousal Populations on Daily Levels of Sleep and Wake
Here, we directly test this hypothesis by a simultaneous triple lesion of these neurons using three saporin-conjugated neurotoxins.
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Anti-Nociceptive and Anti-Allodynic Effects of a High Affinity NOP Hexapeptide [Ac-RY(3-Cl)YRWR-NH2] (Syn 1020) in Rodents
Syn 1020, a NOP receptor directed peptide, administered systemically has anti-nociceptive activity in both acute and chronic pain models in mice and rats respectively.
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SR 16435 [1-(1-(Bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a Novel Mixed Nociceptin/Orphanin FQ/μ-Opioid Receptor Partial Agonist: Analgesic and Rewarding Properties in Mice
We identified a novel nociceptin/orphanin FQ (NOP)/μ-opioid receptor agonist, SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], with high binding affinity and partial agonist activity at both receptors.
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Advanced Patterns and Matches in Link Analysis
The Link Analysis Workbench (LAW) is a tool for detecting and monitoring situations of interest using inexact matching of graphical patterns.
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The comprehensive updated regulatory network of Escherichia coli K-12
One hundred and fifty new interactions have been added to our databases as a result of this specific curation effort, in addition to those added as a result of our…
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Software Supported Pattern Development in Intelligence Analysis
This paper describes the GEM pattern language for encoding analysts’ information needs in graphical patterns, and its use in the Link Analysis Workbench (LAW) system to find inexact matches to…