Bioinformatics publications
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What we do not know about sequence analysis and sequence databases
The marriage of high-throughput nucleotide sequencing with computational methods for the analysis of nucleotide and protein sequences have ushered in a new era of molecular biology.
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EcoCyc: Electronic Encyclopedia of E. coli Genes and Metabolism
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Integrated Pathway/Genome Databases and Their Role in Drug Discovery
We describe pathway-based analyses of the genomes of a number of medically relevant microorganisms, and a novel software tool that provides visualization of gene expression data on a diagram showing…
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EcoCyc: Electronic Encyclopedia of E. coli Genes and Metabolism
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Metabolic Databases
This article will describe some of the uses of these databases and then provide descriptions of the metabolic databases available.
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EcoCyc: Encyclopedia of Escherichia coli genes and metabolism
The encyclopedia of Escherichia coli genes and metabolism (EcoCyc) is a database that combines information about the genome and the intermediary metabolism of E.coli .
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A Collaborative Environment for Authoring Large Knowledge Bases
Collaborative knowledge base (KB) authoring environments are critical for the construction of high-performance KBs. In this paper, we present an environment that satisfies many of these goals.
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EcoCyc: Electronic Encyclopedia of E. coli Genes and Metabolism
The Encyclopedia of E. coli Genes and Metabolism (EcoCyc) is a database that combines information about the genome and the intermediary metabolism of E. coli.
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EcoCyc: Enyclopedia of Escherichia coli Genes and Metabolism
The Encyclopedia of Genes and Metabolism (EcoCyc) is a database that combines information about the genome and the intermediary metabolism of Escherichia coli.
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A Generic Knowledge-Base Browser and Editor
The GKB Editor is a generic editor and browser of knowledge bases (KBs) and ontologies - generic in the sense that it is portable across several frame knowledge representation systems…
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Estimation of Equilibrium Constants Using Automated Group Contribution Methods
Group contribution methods are frequently used for estimating physical properties of compounds from their molecular structures. An algorithm for estimating Gibbs energies of formation through group contribution methods has been…
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Prediction of Enzyme Classification from Protein Sequence without the Use of Protein Similarity
We describe a novel approach for predicting the function of a protein from its amino-acid sequence.