Bioinformatics publications
-
The complete genome sequence of the gastric pathogen Helicobacter pylori
Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification.
-
HinCyc: A Knowledge Base of the Complete Genome and Metabolic Pathways of H. influenzae
We present a methodology for predicting the metabolic pathways of an organism from its genomic sequence.
-
Adapting EcoCyc for Use on the World Wide Web
We have developed a Web server tool, written in Common Lisp, that allows existing graphical user interface applications written using the Common Lisp Interface Manager (CLIM) to hook easily into…
-
Database Links are a Foundation for Interoperability
This article provides an overview of the DB-interoperation problem, and offers several solutions. It discusses how links are used in molecular biology DBs, and describes the potential stumbling blocks when…
-
Integrated Access to Metabolic and Genomic Data
We describe the design and implementation of visual presentations that closely mimic those found in the biology literature, and employ a frame knowledge representation system (FRS) called HyperTHEO to manage…
-
EcoCyc: Electronic Encyclopedia of E. coli Genes and Metabolism
The EcoCyc graphical user interface allows scientists to query and explore the EcoCyc database using visualization tools such as genomic-map browsers and automatic layouts of metabolic pathways.
-
A Protocol for Maintaining Multidatabase Referential Integrity
We propose a network protocol whereby a database administrator can provide information about changes to the identifiers of objects in their database via Internet, to allow other databases to maintain…
-
A vision of database interoperation
-
Adapting CLIM Applications for Use on the World Wide Web
We have developed a Web server tool, written in Common Lisp, that allows any existing graphical user interface application written using the Common Lisp Interface Manager (CLIM) to hook easily…
-
The Generic Frame Protocol
The Generic Frame Protocol (GFP) is an application program interface for accessing knowledge bases stored in frame knowledge representation systems (FRSs).
-
Knowledge Representation in the Large
We describe the design and implementation of a storage subsystem that submerges a database management system (DBMS) within a knowledge representation system.
-
A Storage System for Scalable Knowledge Representation
Our research investigates the hypothesis that one can employ an existing database management system (DBMS) as a storage subsystem for an FRS, to provide high-speed access to large, shared KBs.