Bioinformatics publications
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Automated Drawing of Metabolic Pathways
This paper presents algorithms for drawing metabolic pathways by dynamically querying the underlying knowledge base.
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Representations of Metabolic Knowledge: Pathways
The chief contributions of the paper are a minimized representation for biochemical pathways called the predecessor list, and inference procedures for converting the predecessor list into a pathway-graph representation that…
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Representing, Analyzing, and Synthesizing Biochemical Pathways
This article describes challenges and opportunities for addressing computational problems in the metabolism with techniques from knowledge representation, planning, integration of heterogeneous databases, qualitative reasoning, knowledge acquisition, and machine learning.
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The Grasper-CL Graph Management System
Grasper-CL [5] is a COMMON LISP system for manipulating and displaying graphs, and for building graph-based user interfaces for application programs.
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Frame Representation and Relational Data Bases: Alternative Information-Management Technologies for Systematics
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Representations of Metabolic Knowledge
We survey representations used for several metabolic databases, including EcoCyc, and reach the following conclusions..
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A Qualitative Biochemistry and its Application to the Regulation of the Tryptophan Operon
This article is concerned with the general question of how to represent biological knowledge in computers such that it may be used in multiple problem solving tasks.
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The Design Space of Frame Knowledge Representation Systems
This paper surveys the FRS design space in search of design principles for FRSs.
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A knowledge base of the chemical compounds of intermediary metabolism
This paper describes a publicly available knowledge base of the chemical compounds involved in intermediary metabolism.
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Artificial intelligence methods for theory representation and hypothesis formation
This article describes artificial intelligence methods for representing theories in molecular biology, and for improving the predictive power of these theories using experimental data.
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Hypothesis Formation as Design
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An Analysis of the Distinction Between Deep and Shallow Expert Systems
This paper analyzes the relationship between the techniques used to build expert systems and the behaviors they exhibit to show that there is not sufficient evidence to link the behavioral…