Biomedical sciences publications
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Deficiency of orexin signaling during sleep is involved in abnormal REM sleep architecture in narcolepsy
Here, we determined the activity dynamics of orexin neurons during sleep that suppress the abnormal REM sleep architecture of narcolepsy.
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Identification and characterization of screen use trajectories from late childhood to adolescence in a US-population based cohort study
This study will identify and characterize the subgroups of adolescents sharing similar trajectories of screen use from childhood to adolescence.
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Biological sex influences sleep phenotype in mice experiencing spontaneous opioid withdrawal
We describe here a model of opioid withdrawal in mice that resembles the sleep phenotype characteristic of withdrawal in humans.
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Novel progestogenic androgens for male contraception: design, synthesis, and activity of C7 α-substituted testosterone
Male contraceptive development has included use of testosterone (T) with or without a progestin or the use of a single molecule such as progestogenic androgens (PA) for suppression of testicular…
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Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples
This project used generalized additive mixed models to examine sex-specific development of subcortical volumes and associations with recent alcohol use...
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Higher blood pressure and weight observed among early adolescents during the COVID-19 pandemic
The aim of this study is to quantify differences in blood pressure and weight before and during the COVID-19 pandemic among a demographically diverse national sample of early adolescents.
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The Menstrual Cycle and Sleep
Although objective sleep continuity remains unchanged across the regular, asymptomatic menstrual cycle, activity in the sleep electroencephalogram varies.
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Association of the rs17782313, rs17773430 and rs34114122 Polymorphisms of/near MC4R Gene with Obesity-Related Biomarkers in a Spanish Pediatric Cohort
Our results highlight that metabolic risk factors, especially alterations in carbohydrate metabolism, were related to rs17782313.
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Evaluation of a device-agnostic approach to predict sleep from raw accelerometry data collected by Apple Watch Series 7, Garmin Vivoactive 4, and ActiGraph GT9X Link in children with sleep disruptions
This study demonstrates that raw acceleration data from consumer wearable devices has the potential to be harnessed to predict sleep in children.
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Social epidemiology of Fitbit daily steps in early adolescence
Our objective was to examine differences in device-based step metrics, including daily step count by sociodemographic factors among a diverse sample of 10-to-14-year-old adolescents in the US.
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The mystery of gamma-hydoxybutyrate efficacy in narcolepsy type 1
Over 40 years have elapsed since the original description of the effects of sodium gamma-hydroxybutyrate (GHB) on sleep [1] and the subsequent description of GHB as an effective treatment for…
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Bedtime screen use behaviors and sleep outcomes: Findings from the Adolescent Brain Cognitive Development (ABCD) Study
We aim to determine associations between bedtime screen time behaviors and sleep outcomes in a national study of early adolescents.