Biomedical sciences publications
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Particle radiation-induced dysregulation of protein homeostasis in primary human and mouse neuronal cells
Space particle radiations may cause significant damage to proteins and oxidative stress in the cells within the central nervous system and pose a potential health hazard to humans in long-term…
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Lentivirus Manufacturing Process for Primary T‐Cell Biofactory Production
A process for maximizing the titer of lentivirus particles, deemed to be a necessity for transducing primary cells, is developed.
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Sleep Disturbance Predicts Depression Symptoms in Early Adolescence: Initial Findings From the Adolescent Brain Cognitive Development Study
The aim of the study was to investigate associations between sleep disturbances and mental health in adolescents.
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Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy
These results indicate a functional interaction between orexin and MCH neurons in vivo that suggests the synergistic involvement of these neuronal populations in the sleep/wakefulness cycle.
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Acute Cognitive Effects of the Hypocretin Receptor Antagonist Almorexant Relative to Zolpidem and Placebo: A Randomized Clinical Trial
This study aimed to determine whether ALM produces less acute cognitive impairment than ZOL in human subjects.
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Disturbed Cerebellar Growth Trajectories in Adolescents Who Initiate Alcohol Drinking
The cerebellum is a target of alcoholism-related brain damage in adults, yet no study has prospectively tracked deviations from normal cerebellar growth trajectories in adolescents before and after initiating drinking.
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Trauma-Related Distress During the COVID-19 Pandemic In 59 Countries
This study examined trauma-related distress among 6,882 adults ages 18 to 94 years old in 59 countries during April to May 2020.
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Sensors Capabilities, Performance, and Use of Consumer Sleep Technology
This article reviews how CSTs can process information about sleep, physiology, and environment. The growing number of sensors in wearable devices and the meaning of the data collected are reviewed.
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Shallow Metabolic Depression and Human Spaceflight: A Feasible First Step
Here, we discuss shallow MD as a feasible first step toward synthetic torpor during spaceflight and summarize perspectives following a recent NASA-hosted workshop.
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Sleep and Women’s Health: Sex- And Age-Specific Contributors to Alcohol Use Disorders
As part of the 2018 Research Conference on Sleep and the Health of Women at the National Institutes of Health, three presentations focused on the intersection between alcohol and sleep…
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In Vivo Activity of Amodiaquine against Ebola Virus Infection
We investigated the potential anti-EBOV effect of amodiaquine in a well-characterized nonhuman primate model of EVD.
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Engineered Ovarian Cancer Cell Lines for Validation of CAR T Cell Function
A set of genetically engineered isogenic cell lines is developed to express either folate receptor alpha or mesothelin, and a control cell line negative for both antigens.