Biomedical sciences publications
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REM Sleep-Active MCH Neurons Are Involved in Forgetting Hippocampus-Dependent Memories
Melanin concentrating hormone-producing neurons (MCH neurons) in the hypothalamus actively contribute to forgetting in rapid eye movement (REM) sleep.
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Resources to discover and use short linear motifs in viral proteins
We survey viral uses of SLiMs to mimic host proteins, and information resources available for motif discovery.
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Automatic Artifact Detection in Impedance Cardiogram Using Pulse Similarity Index
We proposed a new algorithm for the automatic detection and exclusion of corrupted ICG cardiac cycles by defining a pulse similarity index that quantifies the level of pulse corruption and…
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Trace Amine-Associated Receptor 1 Agonism Promotes Wakefulness Without Impairment of Cognition in Cynomolgus Macaques
We investigated the effects of TAAR1 agonism in Cynomolgus macaques, a diurnal species that exhibits consolidated night-time sleep, and evaluated the effects of TAAR1 agonists on cognition using a working…
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Wearable Sleep Technology in Clinical and Research Settings
The current state-of-the-art review aims to highlight use, validation and utility of consumer wearable sleep-trackers in clinical practice and research.
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Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats
The generalized stress inherent to head-out plethysmography testing exacerbated the respiratory effects of DSM421 and was possibly compounded by DSM421’s cardiovascular effects, thus artifactually resulting in moribundity and mortality in…
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Excitation of Cortical nNOS/NK1R Neurons by Hypocretin 1 Is Independent of Sleep Homeostasis
We have proposed that cortical nNOS/NK1R interneurons have a role in sleep homeostasis.
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Neurobiological and Immunogenetic Aspects of Narcolepsy: Implications for Pharmacotherapy
Although only a few drugs have received regulatory approval for narcolepsy to date, treatment involves diverse medications that affect multiple biochemical targets and neural circuits.
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Reducing bedtime physiological arousal levels using immersive audio-visual respiratory bio-feedback: a pilot study in women with insomnia symptoms
The current study evaluated the effect of a novel, acute behavioral experimental manipulation in reducing bedtime physiological hyperarousal in women with insomnia symptoms.
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Electrophysiological characterization of sleep/wake, activity and the response to caffeine in adult cynomolgus macaques
We sought to define basal sleep characteristics, sleep/wake architecture and electroencephalographic activity in a diurnal non-human primate (NHP) to evaluate the utility of this species for pharmacological manipulation of the…
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Modular Antigen-Specific T-cell Biofactories for Calibrated In Vivo Synthesis of Engineered Proteins
An artificial cell-signaling pathway is developed that capitalizes on the T-cell’s innate extravasation ability and transforms it into a vector for synthesizing calibrated amounts of engineered proteins in vivo.
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Development of a biodosimeter for radiation triage using novel blood protein biomarker panels in humans and non-human primates
We are developing a rapid screening method to assess whether an individual received an absorbed dose of ≥2 Gy based on the analysis of a specific panel of blood proteins in…