Biomedical sciences publications

We performed chemogenetic excitation of LH neurons in mice and observed increased wakefulness that lasted more than 4 h without unusual behavior or EEG anomalies.

Here, we report that locomotor and EEG spectral responses to the psychostimulants modafinil and caffeine are attenuated in TAAR1 KO mice.

Cholinergic (ACh) basal forebrain (BF) neurons are active during wakefulness and rapid eye movement (REM) sleep and are involved in sleep homeostasis.

Here, we evaluated sleep/wake physiology and behavioral phenotypes of rats with genetic ablation of Nlgn3.

We used the expression of plasticity-related genes to assess synaptic plasticity changes during drug-induced sleep.

This issue of 'Current Opinion of Neurobiology' highlights some of the new research insights into sleep/wake control and sleep function afforded by this expanded research armamentarium.

We used Taar1 knockout and overexpressing mice and TAAR1 agonists to elucidate the role of TAAR1 in sleep/wake. EEG, EMG, body temperature, and locomotor activity were recorded in Taar1 KO,…

As partial agonists at trace amine-associated receptor 1 (TAAR1) promote wakefulness in mice and rats, we evaluated whether TAAR1 agonism had beneficial effects in two mouse models of narcolepsy.

Development of therapeutics for narcolepsy has been challenged by historical misunderstanding of the disease, its many disparate symptoms and, until recently, its unknown etiology.

Early in 1998, we (and others) described the same hypothalamic neuropeptides, respectively called the hypocretins or orexins, which were discovered using two different approaches.