Biomedical sciences publications
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Cntnap2 Knockout Rats and Mice Exhibit Epileptiform Activity and Abnormal Sleep-Wake Physiology
We compared electroencephalogram and behavioral phenotypes of rats and mice with homozygous deletion of Cntnap2, a gene associated with cortical dysplasia-focal epilepsy and autism spectrum disorders.
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Pharmacodynamic Assays to Facilitate Pre-clinical and Clinical Development of Pre-mRNA Splicing Modulatory Drug Candidates
We describe two types of novel pharmacodynamic assays that facilitate drug discovery and development of this intriguing class of innovative therapeutics; the first assay is useful for preclinical optimization of…
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The SRI CLEO Speaker-State Corpus
We introduce the SRI CLEO (Conversational Language about Everyday Objects) Speaker-State Corpus of speech, video, and biosignals.
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Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep
Hypocretin 1 and 2 (Hcrts; also known as orexin A and B), excitatory neuropeptides synthesized in cells located in the tuberal hypothalamus, play a central role in the control of…
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The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems
The dual hypocretin receptor (HcrtR) antagonist almorexant (ALM) may promote sleep through selective disfacilitation of wake-promoting systems, whereas benzodiazepine receptor agonists (BzRAs) such as zolpidem (ZOL) induce sleep through general…
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Hypocretin/orexin Antagonism Enhances Sleep-Related Adenosine and GABA Neurotransmission in Rat Basal Forebrain
We hypothesized that HCRT antagonists induce sleep, in part, through disfacilitation of BF neurons; consequently, ALM should have reduced efficacy in BF-lesioned (BFx) animals.
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Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor
The influenza endonuclease is an essential subdomain of the viral RNA polymerase. It processes host pre-mRNAs to serve as primers for viral mRNA and is an attractive target for antiinfluenza…
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Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington’s Disease
We used a full-length knock-in HD model to determine early changes in the electroencephalogram (EEG) and sleep that may predict the onset and progression of the disease.
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H1N1 infection of sleep/wake regions results in narcolepsy-like symptoms
The neurological basis for narcolepsy resides in the degeneration of the hypothalamic neurons that produce the neuropeptide hypocretin, but how and why these specific cells die is one of the…
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The Neurobiology of Sleep and Wakefulness
Control of sleep and wakefulness involves multiple systems, each of which presents vulnerability to sleep/wake dysfunction that may predispose to physical and/or neuropsychiatric disorders.
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Clinicopathological Features and Prognostic Implications of Raf Kinase Inhibitor Protein Downregulation in Tongue Squamous Cell Carcinoma
In the present study, the expression of RKIP in 85 pairs of TSCC and corresponding adjacent non-cancerous tissues, 30 matched metastatic lesions from the cervical lymph nodes and 32 oral…
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Monocyte Chemotactic Protein-Induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation
Here we report that MCPIP1 interacts with MCPIP4 to form a protein complex but they act independently in regulation of IL-6 mRNA degradation.