Biomedical sciences publications
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Clinicopathological Features and Prognostic Implications of Raf Kinase Inhibitor Protein Downregulation in Tongue Squamous Cell Carcinoma
In the present study, the expression of RKIP in 85 pairs of TSCC and corresponding adjacent non-cancerous tissues, 30 matched metastatic lesions from the cervical lymph nodes and 32 oral…
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Preclinical evaluations to identify optimal linezolid regimens for tuberculosis therapy
Clinically relevant linezolid regimens were simulated in the in vitro hollow-fiber infection model (HFIM) system to identify the linezolid therapies that minimize toxicity, maximize antibacterial activity, and prevent drug resistance.
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Validation of Sleep-Tracking Technology Compared with Polysomnography in Adolescents
Objective- To evaluate the accuracy in measuring nighttime sleep of a fitness tracker (Jawbone UP) compared to polysomnography (PSG).
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What We Know About Primary Dysmenorrhea Today: A Critical Review
This review reports on current knowledge, particularly with regards to the impact and consequences of recurrent menstrual pain on pain sensitivity, mood, quality of life and sleep in women with…
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Refining Measurement of Substance Use Disorders among Women of Child-Bearing Age Using Hospital Records: The Development of the Explicit-Mention Substance Abuse Need for Treatment in Women (EMSANT-W) Algorithm
This article presents the development of the Explicit Mention Substance Abuse Need for Treatment in Women (EMSANT-W), a gender-tailored tool based upon existing International Classification of Diseases, 9th Edition, Clinical…
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Challenges of Metagenomics and Single-Cell Genomics Approaches for Exploring Cyanobacterial Diversity
We briefly review current sequencing technologies and their innovative uses in genomics and metagenomics.
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Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson’s disease
The present review attempts to provide an overview of our current understanding of dyskinesia and other L-dopa-induced dysfunctions, a field that dramatically evolved in the past twenty years.
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Prediction of heart rate changes from speech features during interaction with a misbehaving dialog system
This study examines two questions: how do undesirable system responses affect people physiologically, and to what extent can we predict physiological changes from the speech signal alone?
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Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice?
This review will summarize the current state of knowledge regarding HERV-K and cancer and attempt to outline the potential mechanisms by which HERV-K could be involved in the onset and…
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The spliceosome is a therapeutic vulnerability in MYC-driven cancer
Here we discover that the spliceosome is a new target of oncogenic stress in MYC-driven cancers. We identify BUD31 as a MYC-synthetic lethal gene in human mammary epithelial cells, and…
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The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia.
We report that the spliceosome modulator sudemycin induces selective cytotoxicity in primary chronic lymphocytic leukemia (CLL) cells when compared with healthy lymphocytes and tumor cells from other B-lymphoid malignancies, with…
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SR-2P vaginal microbicide gel provides protection against herpes simplex virus 2 when administered as a combined prophylactic and postexposure therapeutic
Here, we show that a dose of SR-2P administered 24 h prior to infection provides some protection against the virus, but to a lesser degree than SR-2P administered either once…