Biomedical sciences publications
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Clock Genes X Stress X Reward Interactions in Alcohol and Substance Use Disorders
The aim of the present review is to summarize findings linking clock genes, stress, and alcohol and substance abuse, and to propose potential underlying neurobiological mechanisms.
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Addiction, Freedom, and Responsibility
In his article supporting an evolutionary perspective of free will, John Banja (2015) argues that addicts are responsible for their addictive behaviors because they could engage in practices that would diminish…
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Brain Development in Heavy-Drinking Adolescents
The authors measured within-subject changes in regional brain morphometry over longer intervals and in larger samples of adolescents than previously reported and assessed differences between adolescents who remained nondrinkers and…
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K12 CS Teaching Methods Courses
CS teacher development has become a major effort for the SIGCSE community in part due to NSF's CS10K efforts and expanding CSTA involvement. However there are few examples of university…
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Characterization of Batracylin-Induced Renal and Bladder Toxicity in Rats
To further investigate batracylin’s mechanism of toxicity, studies were conducted in Fischer 344 rats. Once daily oral administration of 16 or 32 mg/kg batracylin to rats for 4 days caused…
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Cardiac Autonomic Function During Sleep: Effects of Alcohol Dependence and Evidence of Partial Recovery with Abstinence
Chronic alcoholism is associated with the development of cardiac and peripheral autonomic nervous system (ANS) pathology.
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Evidence for a Role for alpha6 nAChRs in L-Dopa-Induced Dyskinesias Using Parkinsonian alpha6 nAChR Gain-of-Function Mice
Here we investigate the role of α6β2* nAChRs, a subtype selectively present in the nigrostriatal pathway, using α6 nAChR subunit null mutant (α6(-/-)) mice.
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Women with Dysmenorrhoea Are Hypersensitive to Experimentally Induced Forearm Ischaemia During Painful Menstruation and During the Pain-Free Follicular Phase
We investigated whether women with dysmenorrhoea, compared with controls, have increased sensitivity to experimentally induced deep-tissue muscle ischaemia in a body area distant from that of referred menstrual pain.
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Bioprotective Carnitinoids: Lipoic Acid, Butyrate, and Mitochondria-Targeting to Treat Radiation Injury: Mitochondrial Drugs Come of Age
There is an urgent need for effective medicines to protect against and treat the harmful biological effects of radiation . Potential strategies herein include mitochondrial and epigenetic-driven methods using lipoic…
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Activation of alpha2-Adrenergic Receptor by (R,R’)-4′-Methoxy-1-Naphthylfenoterol Inhibits Proliferation and Motility of Melanoma Cells
Taken together, these results identified β2-AR as a novel potential target for melanoma management, and (R,R')-MNF as an efficient trigger of anti-tumorigenic cAMP/PKA-dependent signaling in β2-AR-expressing lesions.
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Pharmacological Characterization of RO5461861, a Potent and Selective PDE10A Inhibitor
We describe the characterization of a new class of potent PDE10A inhibitors exemplified by 4-(Azetidine-1 -carbonyl)-2-methyl-2-H-pyrazole-3-carboxylic acid (2-phenylimidazo[1,2-a]pyrimidin-7-yl)-amide (RO5461861) in vitro as well as in behavioral tests relevant to NMDA-R…
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Biodistribution of the Multidentate Hydroxypyridinonate Ligand [(14) C]-3,4,3-Li(1,2-HOPO), a Potent Actinide Decorporation Agent
The pharmacokinetics and biodistribution of the 14C-labeled actinide decorporation agent 3,4,3-LI(1,2-HOPO) were investigated in young adult Swiss Webster mice and Sprague Dawley rats, after intravenous, intraperitoneal, and oral dose administration.