Biomedical sciences publications
-
Unravelling Glucan Recognition Systems by Glycome Microarrays Using the Designer Approach and Mass Spectrometry
We describe construction of a "glucome" microarray, the first sequence-defined glycome-scale microarray, using a "designer" approach from targeted ligand-bearing glucans in conjunction with a novel high-sensitivity mass spectrometric sequencing method.
-
Preclinical Studies on the Pharmacokinetics, Safety, and Toxicology of Oxfendazole: Toward First in Human Studies
A 2-week study in rats identified target organs of oxfendazole toxicity to be bone marrow, epididymis, liver, spleen, testis, and thymus.
-
Formulation Approaches to Improving the Delivery of an Antiviral Drug with Activity against Seasonal Flu
The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches.
-
Pharmacokinetics and Metabolism of 4R-Cembranoid
The purpose of this study was to examine the metabolism and pharmacokinetics of 4R as part of its preclinical development as a neuroprotective drug.
-
Targeting N-Glycan Cryptic Sugar Moieties for Broad-Spectrum Virus Neutralization: Progress in Identifying Conserved Molecular Targets in Viruses of Distinct Phylogenetic Origins
In this study, we characterized two broadly HIV-neutralizing agents, human monoclonal antibody 2G12 and Galanthus nivalis lectin (GNA), for their viral targeting activities.
-
K12 CS Teaching Methods Courses
BOF attendees are asked to bring materials from their classes and be ready to discuss multiple viewpoints about topics, pedagogical strategies and readings from a rich history of research in…
-
Emergence of terpene cyclization in Artemisia annua
Here we report the first discovery of an epistatic network of residues that controls the onset of terpene cyclization in Artemisia annua.
-
Future Approaches to Therapeutic Hypothermia: A Symposium Report
The current session demonstrates the use of wireless technologies for monitoring several physiological variables in freely moving rodents, and reviews advances in analytical techniques for the detection of adenosine which…
-
Plasmodium vivax trophozoite-stage proteomes
Data from two of three biological replicate proteomes, emphasized here, were analyzed using five search engines, which enhanced identifications and resulted in the most comprehensive P. vivax proteomes to date.
-
Methods of Association and Dissociation for Establishing Selective Brain-Behavior Relations
Methods for identifying and understanding brain structure–function relations have evolved over the past century, from astute observations of selective impairments associated with focal brain damage to dissociations measured by combining…
-
Tablet formulation of an active pharmaceutical ingredient with a sticking and filming problem: direct compression and dry granulation evaluations
Direct compression and dry granulation tableting techniques were evaluated using factorial experimental design.
-
Introduction of plasmid encoding for rare tRNAs reduces amplification bias in phage display biopanning
Here we present a method that reduces amplification bias by addition of a plasmid that encodes six low abundance tRNAs into K91 Escherichia coli.