Biomedical sciences publications
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Synthesis and Optimization of Small Molecule Inhibitors of Prostate Specific Antigen
We identified a compound as a 216 nM inhibitor of a prostate-specific antigen with better stability in media than triazole B1 and evaluated the selectivity profile of the compound by…
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Using Wearable Skin Temperature Data to Advance Tracking and Characterization of the Menstrual Cycle in a Real-World Setting
Here, we show that the menstrual skin temperature variation is better represented by a model of oscillation, the cosinor, than by a biphasic square wave model.
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Multi-dimensional predictors of first drinking initiation and regular drinking onset in adolescence: A prospective longitudinal study.
Early adolescent drinking onset is linked to myriad negative consequences. Using the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) baseline to year 8 data, this study (1) leveraged…
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Multi-level prediction of substance use: Interaction of white matter integrity, resting-state connectivity and inhibitory control measured repeatedly in every-day life
Substance use disorders are characterized by inhibition deficits related to disrupted connectivity in white matter pathways, leading via interaction to difficulties in resisting substance use. By combining neuroimaging with smartphone-based…
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Contributions of cerebral white matter hyperintensities, age, and pedal perception to postural sway in people with HIV
With aging, people with HIV (PWH) have diminishing postural stability that increases liability for falls. Factors and neuromechanisms contributing to instability are incompletely known. Brain white matter abnormalities seen as…
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Identifying high school risk factors that forecast heavy drinking in understudied young adults
Heavy alcohol drinking is a major, preventable problem that adversely impacts the physical and mental health of US young adults. Studies seeking drinking risk factors typically focus on young adults…
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Serum albumin and white matter hyperintensities
Here, a sample including 160 individuals with alcohol use disorders, 142 living with HIV, and 102 healthy controls was used to test the hypothesis that serum albumin would be inversely…
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Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design
We describe the protocol for the Pediatric Observational Cohort Study of the NIH’s REsearching COVID to Enhance Recovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta-cohort study of caregiver-child pairs (birth…
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Distinct lateral hypothalamic CaMKIIα neuronal populations regulate wakefulness and locomotor activity
Here, we show that LH Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα)-expressing neurons are active during wakefulness and that chemogenetic excitation of these neurons induces sustained wakefulness and increased locomotor activity even…
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Delayed effects of radiation exposure in a C57L/J mouse model of partial body irradiation with ~2.5% bone marrow shielding
The objective of this manuscript is to describe the dose response relationship and progression of radiation injury and to evaluate its suitability for use in delayed effects of acute radiation…
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Investigating the origin of the 13C lactate signal in the anesthetized healthy rat brain in vivo after hyperpolarized [1-13C]pyruvate injection
The goal of this study was to investigate the origin of brain lactate (Lac) signal after injection of hyperpolarized (HP) [1-13C]pyruvate (Pyr).
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Age-Accelerated Increase of White Matter Hyperintensity Volumes Is Exacerbated by Heavy Alcohol Use in People Living With HIV
Antiretroviral treatment has enabled people living with HIV infection to have a near-normal life span. With longevity comes opportunities for engaging in risky behavior, including initiation of excessive drinking. Given…