Biomedical sciences publications
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Biomarkers of Response to Smoking Cessation Pharmacotherapies: Progress to Date
Recent research has begun to determine biomarkers (such as genotype, nicotine and metabolite levels, and brain imaging findings) that may have utility in predicting smoking cessation.
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Classification of Lexical Stress Using Spectral and Prosodic Features for Computer-assisted Language Learning Systems
We present a system for detection of lexical stress in English words spoken by English learners. This system was designed to be part of the EduSpeak® computer-assisted language learning (CALL)…
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Activation of alpha2-Adrenergic Receptor by (R,R’)-4′-Methoxy-1-Naphthylfenoterol Inhibits Proliferation and Motility of Melanoma Cells
Taken together, these results identified β2-AR as a novel potential target for melanoma management, and (R,R')-MNF as an efficient trigger of anti-tumorigenic cAMP/PKA-dependent signaling in β2-AR-expressing lesions.
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Pharmacological Characterization of RO5461861, a Potent and Selective PDE10A Inhibitor
We describe the characterization of a new class of potent PDE10A inhibitors exemplified by 4-(Azetidine-1 -carbonyl)-2-methyl-2-H-pyrazole-3-carboxylic acid (2-phenylimidazo[1,2-a]pyrimidin-7-yl)-amide (RO5461861) in vitro as well as in behavioral tests relevant to NMDA-R…
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Biodistribution of the Multidentate Hydroxypyridinonate Ligand [(14) C]-3,4,3-Li(1,2-HOPO), a Potent Actinide Decorporation Agent
The pharmacokinetics and biodistribution of the 14C-labeled actinide decorporation agent 3,4,3-LI(1,2-HOPO) were investigated in young adult Swiss Webster mice and Sprague Dawley rats, after intravenous, intraperitoneal, and oral dose administration.
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Characterization of cyclic peptides containing disulfide bonds
Three peptides that belong to this category, p-Cl-Phe-DPDPE, DPDPE, and CTOP, were analyzed and the results are presented in this paper.
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Practical Measures of Learning Behaviors
This paper argues that improving learning reliably and at scale requires a specific orientation toward measurement, understood broadly.
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High Frequency Neuronal Oscillations in a Cynomolgus Macaque Test of Working Memory Following NMDA Receptor Antagonism
Disruptions in sensory processing and abnormal temporal integration of neuronal oscillations have been identified in schizophrenic patients and may contribute to poor performance in working memory task testing.
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Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers Despite Associations with Baseline Smoking
We observed no significant associations between CHRNA5-A3-B4 variants and smoking cessation, despite replicating previous associations with baseline tobacco consumption.
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Reduced Cerebral and Cardiovascular Hemodynamics During Sustained Affective Stimulation in Young Women with Chronic Low Blood Pressure
We assessed central and peripheral hemodynamic changes in 15 undergraduate women with chronic hypotension and 15 normotensive controls during sustained exposure to pleasant, unpleasant and neutral pictures.
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Dynamic Responses of Selective Brain White Matter Fiber Tracts to Binge Alcohol and Recovery in the Rat
To determine the dynamics of white matter vulnerability to excessive alcohol consumption, diffusion tensor imaging (DTI) was used in an animal model of alcohol exposure.
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Discovery of the First Small-Molecule Opioid Pan Antagonist with Nanomolar Affinity at Mu, Delta, Kappa, and Nociceptin Opioid Receptors
Since this is the first ligand containing the trans-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist pharmacophore to have affinity for the NOP receptor, we explored the structural determinants of its NOP binding affinity.