Biomedical sciences publications
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Modular Three-component Delivery System Facilitates HLA Class I Antigen Presentation and CD8(+) T-Cell Activation against Tumors
Here we present a nanoparticle delivery system that facilitates presentation of an immunogenic measles antigen specifically in cancer cells.
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Nitrocobinamide, a New Cyanide Antidote That Can Be Administered by Intramuscular Injection
Here we show that adding sodium nitrite to cobinamide yields a stable derivative that rescues cyanide-poisoned mice and rabbits when given by intramuscular injection.
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Homeostatic Sleep Pressure Is the Primary Factor for Activation of Cortical nNOS/NK1 Neurons
Cortical interneurons, immunoreactive for neuronal nitric oxide synthase (nNOS) and the receptor NK1, express the functional activity marker Fos selectively during sleep. NREM sleep ‘pressure’ is hypothesized to accumulate...
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Varenicline Enhances Dopamine Release Facilitation More Than Nicotine after Long-Term Nicotine Treatment and Withdrawal
Here, we used real-time cyclic voltammetry in brain slices containing the nucleus accumbens to further elucidate the changes in dopamine release linked to nicotine withdrawal.
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Biological Effectiveness of Photons and Electrons as a Function of Energy
Because of the enormous complexity of the phenomena involved, it is unlikely that any single area of study can provide a clear understanding of the relative biological effectiveness of different…
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Future Approaches to Therapeutic Hypothermia: A Symposium Report
The current session demonstrates the use of wireless technologies for monitoring several physiological variables in freely moving rodents, and reviews advances in analytical techniques for the detection of adenosine which…
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Plasmodium vivax trophozoite-stage proteomes
Data from two of three biological replicate proteomes, emphasized here, were analyzed using five search engines, which enhanced identifications and resulted in the most comprehensive P. vivax proteomes to date.
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Methods of Association and Dissociation for Establishing Selective Brain-Behavior Relations
Methods for identifying and understanding brain structure–function relations have evolved over the past century, from astute observations of selective impairments associated with focal brain damage to dissociations measured by combining…
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Tablet formulation of an active pharmaceutical ingredient with a sticking and filming problem: direct compression and dry granulation evaluations
Direct compression and dry granulation tableting techniques were evaluated using factorial experimental design.
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Quantitative Susceptibility Mapping by Inversion of a Perturbation Field Model: Correlation with Brain Iron in Normal Aging
We present a method for quantifying susceptibility by inversion of a perturbation model, or “QSIP.” The perturbation model relates phase to susceptibility using a kernel calculated in the spatial domain,…
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Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences
To assess the relative contribution of heritable versus non-heritable factors, we have performed a systems-level analysis of 210 healthy twins between 8 and 82 years of age.
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Fast and Ultrafast Kelvin Wave Modulations of the Equatorial Evening F Region Vertical Drift and Spread F Development
In this paper, we investigate the role of eastward and upward propagating fast and ultrafast Kelvin waves in the day-to-day variability of equatorial evening prereversal vertical drift and post sunset…