Biomedical sciences publications
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Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences
To assess the relative contribution of heritable versus non-heritable factors, we have performed a systems-level analysis of 210 healthy twins between 8 and 82 years of age.
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Fast and Ultrafast Kelvin Wave Modulations of the Equatorial Evening F Region Vertical Drift and Spread F Development
In this paper, we investigate the role of eastward and upward propagating fast and ultrafast Kelvin waves in the day-to-day variability of equatorial evening prereversal vertical drift and post sunset…
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The alpha7 Nicotinic Receptor Agonist ABT-107 Protects against Nigrostriatal Damage in Rats with Unilateral 6-Hydroxydopamine Lesions
The objective of this study was twofold: first, to test the protective potential of ABT-107, an agonist with high selectivity for α7 nAChRs; and second, to investigate its cellular mechanism…
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Measuring and Statistically Testing the Size of the Effect of a Chemical Compound on a Continuous in-Vitro Pharmacological Response through a New Statistical Model of Response Detection Limit
We used a linearized version of this equation to define a measure of pharmacological effect size, and use this measure to rank the investigated compounds in order of their overall…
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Characterization, HPLC Method Development and Impurity Identification for 3,4,3-Li(1,2-HOPO), a Potent Actinide Chelator for Radionuclide Decorporation
Derivatization of the target ligand in situ with Fe(III) chloride provided a single homogeneous iron-complex that can readily be detected and analyzed by HPLC.
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Cytotoxicity of Human Endogenous Retrovirus K-Specific T Cells toward Autologous Ovarian Cancer Cells
Endogenous retroviral gene products in ovarian cancer may represent a potentially valuable new pool of tumor-associated antigens for targeting of therapeutic vaccines to ovarian cancer.
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Tenofovir Disoproxil Fumarate: Toxicity, Toxicokinetics, and Toxicogenomics Analysis After 13 Weeks of Oral Administration in Mice
The goals of this study were to evaluate the molecular mechanism of TDF-induced toxicity in mice by correlating transcriptional changes with plasma drug levels and traditional toxicology end points.
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Functional variants in CYP1A1 and GSTM1 are associated with clearance of cervical HPV infection
We evaluated time to clearance of high risk (HR) HPV infection in relation to functional variants in three genes (CYP1A1, GSTT1, and GSTM1).
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Effects of Nmda Receptor Antagonism on High Frequency Neuronal Oscillations and Working Memory Performance in Cynomolgus Macaques
Our results suggest that acute administration of a NMDA receptor antagonist disrupts neuronal oscillations and cognitive processing and this may contribute to impaired cognitive performance in macaques.
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HTLV-1-Infected CD4+ T-Cells Display Alternative Exon Usages That Culminate in Adult T-Cell Leukemia
We hypothesized that besides quantitative transcriptional effects, HTLV-1 qualitatively modifies the pattern of cellular gene expression.
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Quantitative Proteomics for Cardiac Biomarker Discovery Using Isoproterenol-Treated Nonhuman Primates
To identify new cardiac biomarkers, a quantitative proteomic analysis has been performed on serum and heart tissue proteins from three species of nonhuman primates following isoproterenol (ISO) treatment.
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Formulation Development and Evaluation of Innovative Two-Polymer (SR-2P) Bioadhesive Vaginal Gel
The main objective of this investigation was to study the feasibility of developing a vaginal bioadhesive microbicide using a SRI’s proprietary two-polymer gel platform (SR-2P).