Biomedical sciences publications
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Singlet Molecular Oxygen Formation by O-Atom Recombination on Fused-Quartz Surfaces
Experimental results demonstrate O2(aΔ1g) (υ=0) formation by catalytic O-atom surface recombination in a room-temperature fused-quartz flow-tube reactor.
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BU08073 a Buprenorphine Analog with Partial Agonist Activity at mu Receptors in vitro but Long-Lasting Opioid Antagonist Activity in vivo in Mice
Structure activity studies were conducted to design buprenorphine analogues with high affinity at each of these receptors and to characterize them in in vitro and in vivo assays.
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Quantitative Susceptibility Mapping by Inversion of a Perturbation Field Model: Correlation with Brain Iron in Normal Aging
We present a method for quantifying susceptibility by inversion of a perturbation model, or “QSIP.” The perturbation model relates phase to susceptibility using a kernel calculated in the spatial domain,…
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Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences
To assess the relative contribution of heritable versus non-heritable factors, we have performed a systems-level analysis of 210 healthy twins between 8 and 82 years of age.
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The alpha7 Nicotinic Receptor Agonist ABT-107 Protects against Nigrostriatal Damage in Rats with Unilateral 6-Hydroxydopamine Lesions
The objective of this study was twofold: first, to test the protective potential of ABT-107, an agonist with high selectivity for α7 nAChRs; and second, to investigate its cellular mechanism…
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Fast and Ultrafast Kelvin Wave Modulations of the Equatorial Evening F Region Vertical Drift and Spread F Development
In this paper, we investigate the role of eastward and upward propagating fast and ultrafast Kelvin waves in the day-to-day variability of equatorial evening prereversal vertical drift and post sunset…
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Tenofovir Disoproxil Fumarate: Toxicity, Toxicokinetics, and Toxicogenomics Analysis After 13 Weeks of Oral Administration in Mice
The goals of this study were to evaluate the molecular mechanism of TDF-induced toxicity in mice by correlating transcriptional changes with plasma drug levels and traditional toxicology end points.
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Tyrosine 308 Is Necessary for Ligand-Directed Gs-Biased Signaling of Beta2-Adrenoceptor
Here, using docking simulation and site-directed mutagenesis, we defined Tyr-308 as the key amino acid residue on β2-AR essential for Gs-biased signaling.
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Functional variants in CYP1A1 and GSTM1 are associated with clearance of cervical HPV infection
We evaluated time to clearance of high risk (HR) HPV infection in relation to functional variants in three genes (CYP1A1, GSTT1, and GSTM1).
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Effects of Nmda Receptor Antagonism on High Frequency Neuronal Oscillations and Working Memory Performance in Cynomolgus Macaques
Our results suggest that acute administration of a NMDA receptor antagonist disrupts neuronal oscillations and cognitive processing and this may contribute to impaired cognitive performance in macaques.
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Quantitative Proteomics for Cardiac Biomarker Discovery Using Isoproterenol-Treated Nonhuman Primates
To identify new cardiac biomarkers, a quantitative proteomic analysis has been performed on serum and heart tissue proteins from three species of nonhuman primates following isoproterenol (ISO) treatment.
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HTLV-1-Infected CD4+ T-Cells Display Alternative Exon Usages That Culminate in Adult T-Cell Leukemia
We hypothesized that besides quantitative transcriptional effects, HTLV-1 qualitatively modifies the pattern of cellular gene expression.