Biomedical sciences publications
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Compromised Frontocerebellar Circuitry Contributes to Nonplanning Impulsivity in Recovering Alcoholics
We tested the hypothesis that alcoholic patients would demonstrate compromised dorsal anterior cingulate cortex (dACC) -cerebellar functional connectivity when adjusting their strategies to accommodate uncertain conditions and would recruit compensatory…
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Formulation Development and Evaluation of Innovative Two-Polymer (SR-2P) Bioadhesive Vaginal Gel
The main objective of this investigation was to study the feasibility of developing a vaginal bioadhesive microbicide using a SRI’s proprietary two-polymer gel platform (SR-2P).
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Magnitude of the Impact of Hot Flashes on Sleep in Perimenopausal Women
The presence of physiological hot flashes accounts for a significant proportion of total objective time awake during the night in perimenopausal women.
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Organic Cation Transporter Variation and Response to Smoking Cessation Therapies
We evaluated chr6q25.3 organic cation transporter gene (SLC22A1, SLC22A2, SLC22A3) variation and response to smoking cessation therapies.
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Peer Status among Incarcerated Female Offenders: Associations with Social Behavior and Adjustment
Using a peer nomination technique in a sample of incarcerated females, our study is the first to examine the association between peer status and psychopathology in a correctional facility.
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Overlapping and Distinct Molecular Determinants Dictating the Antiviral Activities of Trim56 against Flaviviruses and Coronavirus
We show that TRIM56 poses a barrier to infections by yellow fever virus (YFV), dengue virus serotype 2 (DENV2), and human coronavirus virus (HCoV) OC43 but not encephalomyocarditis virus (EMCV).
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Prophylactic treatment with a novel bioadhesive gel formulation containing aciclovir and tenofovir protects from HSV-2 infection
Over-the-counter access to an inexpensive, effective topical microbicide could reduce the transmission of HIV and would increase women’s control over their health and eliminate the need to obtain their partners’…
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Tyrosine 308 Is Necessary for Ligand-Directed Gs-Biased Signaling of Beta2-Adrenoceptor
Here, using docking simulation and site-directed mutagenesis, we defined Tyr-308 as the key amino acid residue on β2-AR essential for Gs-biased signaling.
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Brain Metabolite Levels as Predictors of Abstinance or Relapse in Alcohol Use Disorders
This in vivo magnetic resonance spectroscopy study included 15 control subjects and 20 recently sober individuals with alcohol use disorders.
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Varenicline Enhances Dopamine Release Facilitation after Long-Term Nicotine Treatment and Withdrawal
Here, we used real-time cyclic voltammetry in brain slices containing the nucleus accumbens to further elucidate the changes in dopamine release linked to nicotine withdrawal.
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Folate and Vitamin B12 May Play a Critical Role in Lowering the HPV 16 Methylation-Associated Risk of Developing Higher Grades of CIN
The purpose of the current study was to replicate our previous findings and to evaluate the influence of plasma concentrations of folate and vitamin B12 on the degree of HPV…
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Novel Human Radiation Exposure Biomarker Panel Applicable for Population Triage
We aimed to identify a panel of radiation-responsive plasma proteins that could be used in a point-of-care biologic dosimeter to detect clinically significant levels of ionizing radiation exposure