Biomedical sciences publications
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Imaging Neuroinflammation? A Perspective from MR Spectroscopy
The present MRS study was conducted in four groups: alcohol dependent, HIV-infected, alcohol dependent + HIV infected and healthy control individuals to determine whether metabolites would change in a pattern reflecting neuroinflammation.
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(R,S)-Ketamine Metabolites (R,S)-Norketamine and (2S,6S)-Hydroxynorketamine Increase the Mammalian Target of Rapamycin Function
Subanesthetic doses of (R,S)-ketamine are used in the treatment of neuropathic pain and depression.
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miRNA and Autophagy in the Pharmacological Gaucher Mouse Model
This study investigates early stage pathogenetic targets that contribute to degeneration in Gaucher disease, Parkinson’s disease (PD) and Gaucher-related PD.
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Brain Metabolite Levels as Predictors of Abstinance or Relapse in Alcohol Use Disorders
This in vivo magnetic resonance spectroscopy study included 15 control subjects and 20 recently sober individuals with alcohol use disorders.
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Varenicline Enhances Dopamine Release Facilitation after Long-Term Nicotine Treatment and Withdrawal
Here, we used real-time cyclic voltammetry in brain slices containing the nucleus accumbens to further elucidate the changes in dopamine release linked to nicotine withdrawal.
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Folate and Vitamin B12 May Play a Critical Role in Lowering the HPV 16 Methylation-Associated Risk of Developing Higher Grades of CIN
The purpose of the current study was to replicate our previous findings and to evaluate the influence of plasma concentrations of folate and vitamin B12 on the degree of HPV…
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Novel Human Radiation Exposure Biomarker Panel Applicable for Population Triage
We aimed to identify a panel of radiation-responsive plasma proteins that could be used in a point-of-care biologic dosimeter to detect clinically significant levels of ionizing radiation exposure
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The α7 nicotinic receptor agonist ABT-107 decreases L-Dopa-induced dyskinesias in parkinsonian monkeys
Since rodent studies also suggested an involvement of α7 nAChRs in LIDs, we tested the effect of the potent, selective α7 agonist ABT-107 [5-(6-[(3R)-1-azabicyclo[2.2.2]oct-3-yloxy] pyridazin-3-yl)-1H-indole].
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Interhemispheric Functional Connectivity Change Is Linked to Callosal Fiber Integrity Change over a 1-Year Follow-up in Chronic Alcoholics
We tested whether microstructural fiber changes relate to resting-state functional connectivity changes in alcoholics who have maintained sobriety during a one-year interval, and whether these changes are beyond those potentially…
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The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions.
The finding that smoking is inversely correlated with Parkinson’s disease and that nicotine attenuates nigrostriatal damage in Parkinsonian animals supports the idea that nicotine may be neuroprotective.
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Structure-Based Virtual Screening of the Nociceptin Receptor: Hybrid Docking and Shape-Based Approaches for Improved Hit Identification
In this study, we explored the use of the active-state NOP homology model for structure-based virtual screening to discover NOP ligands containing new chemical scaffolds.
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Alcohol and the Sleeping Brain
This chapter outlines the evidence for acute and chronic alcohol effects on sleep architecture and sleep electroencephalogram, evidence for tolerance with repeated administration, and possible underlying neurochemical mechanisms for alcohol's…