Biomedical sciences publications

We have used NMR spectroscopy to characterize an oligonucleotide stem loop structure based on the pre-element of an oncogenic microRNA, miR-21.

In this paper, we consider the roles in a biology textbook, adapt a definition of roles based on upper ontologies, and relate it to the corresponding notions in linguistics and…

Our study aimed to investigate haemodynamic and behavioural responses during emotional stimulation in narco-cataplexy.

We investigated the association between CHRNA5-A3-B4 and smoking abstinence. The rs2056527(A) allele was associated with lower abstinence with active pharmacotherapy, or with nicotine gum alone but not significantly with bupropion.

We have developed preliminary laboratory data for formation of volatile aldehydes produced by oxidatation of amino acids found in ELF exposed to HOCl. Formation of HOCl, via oxidation of chloride…

Zanamivir (Relenza™) and oseltamivir (Tamiflu(®)) are two antiviral drugs currently recommended by the CDC for treating influenza. Both are examples of the successful application of structure-based drug design strategies.

In this process, doxcycline was oxidized to the N-oxide using m-CPBA. The hydrochloride salt of the tertiary N-oxide was treated with Fe(0)/FeCl3 catalyst yielding the N-demethylated product.

Here we demonstrate that redirection of primary human T cells with a CAR containing the inducible costimulator (ICOS) intracellular domain generates tumor-specific IL-17-producing effector cells that show enhanced persistence.

This study demonstrates the presence of sleep/wake abnormalities in a model of ASD, consistent with the presence of sleep disruptions found in ASD. The observed decreases in NREM and increased…