Biomedical sciences publications
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The Feasibility of Assessing Branched-Chain Amino Acid Metabolism in Cellular Models of Prostate Cancer with Hyperpolarized [1-(13)C]-Ketoisocaproate
Our goals were to investigate branched-chain aminotransferase (BCAT) activity in prostate cancer with a novel molecular probe, hyperpolarized [1-(13)C]-2-ketoisocaproate ([1-(13)C]-KIC), and explore the potential of branched-chain amino acid (BCAA) metabolism…
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Human Endogenous Retrovirus K Expression Predicts a Prostate Cancer Diagnosis
This review will summarize the current state of knowledge regarding HERV-K and cancer and attempt to outline the potential mechanisms by which HERV-K could be involved in the onset and…
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Nocturnal Cardiac Autonomic Profile in Young Primary Insomniacs and Good Sleepers
We investigated cardiac vagal and sympathetic activity in 13 young primary insomniacs and 14 good sleepers during nocturnal sleep.
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Toward a Breathable Biomarker for Physiological Stress
We have developed preliminary laboratory data for formation of volatile aldehydes produced by oxidatation of amino acids found in ELF exposed to HOCl. Formation of HOCl, via oxidation of chloride…
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Recent Advances in Computer-Aided Drug Design as Applied to Anti-Influenza Drug Discovery
Zanamivir (Relenza™) and oseltamivir (Tamiflu(®)) are two antiviral drugs currently recommended by the CDC for treating influenza. Both are examples of the successful application of structure-based drug design strategies.
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Synthesis of Doxycycline-[(CD3)-C-13]
In this process, doxcycline was oxidized to the N-oxide using m-CPBA. The hydrochloride salt of the tertiary N-oxide was treated with Fe(0)/FeCl3 catalyst yielding the N-demethylated product.
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ICOS-Based Chimeric Antigen Receptors Program Bipolar Th17/Th1 Cells
Here we demonstrate that redirection of primary human T cells with a CAR containing the inducible costimulator (ICOS) intracellular domain generates tumor-specific IL-17-producing effector cells that show enhanced persistence.
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Characterization of Genetic Variation in the Vgll4 Gene in Anorexia Nervosa
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Sleep/Wake Regulation and Cortical EEG Are Disturbed in the Neuroligin-3 Rat Model of Autism
This study demonstrates the presence of sleep/wake abnormalities in a model of ASD, consistent with the presence of sleep disruptions found in ASD. The observed decreases in NREM and increased…
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Development of an Agonist of the TGF-Beta Signaling Pathway to Treat Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder that leads to progressive cognitive dysfunction. Current knowledge of the processes leading to AD is still limited, and no effective treatments are available.…
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5′-AMP-Activated Protein Kinase (AMPK) Supports the Growth of Aggressive Experimental Human Breast Cancer Tumors
Here, we used triple-negative human breast cancer cells in which AMPK activity had been knocked down to investigate the contribution of AMPK to experimental tumor growth and core glucose metabolism.
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Building a Breathprint: Biomarkers of Exposure Due to the Toxicant Trochloroethylene
Our pilot studies indicate that we can detect TCE and other VOCs in the breath environment that are indicative of neuronal degeneration. Pending studies will investigate the relationship between toxicant exposure…