Biomedical sciences publications
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Association between Personality Traits and DSM-IV Diagnosis of Insomnia in Peri- and Postmenopausal Women
The aim of this study was to determine the role of personality factors in the development of DSM-IV insomnia coincident with perimenopause.
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Evidence for the Role of EPHX Gene Variants in Anorexia Nervosa
To identify genetic variants associated with AN, we pursued a series of sequencing and genotyping studies focusing on the coding regions and upstream sequence of 152 candidate genes in a…
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Regional Manifold Learning for Disease Classification
We use the regional manifolds as low-dimensional descriptors of high-dimensional morphological image features, which are then fed into a classifier to identify regions affected by disease.
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Effect of Bitopertin, a Glycine Reuptake Inhibitor, on Negative Symptoms of Schizophrenia: A Randomized, Double-Blind, Proof-of-Concept Study
Our objective is to determine the efficacy and safety of bitopertin (RG1678), a glycine reuptake inhibitor, in patients with schizophrenia and predominant negative symptoms who were stable while taking an…
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Evidence of Recovery in Cortico-Cardiac Activity During Sleep in Recently Detoxified Alcoholics
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Sleep EEG Evidence of Early Brain Recovery with Abstinence in Long-Term Alcoholics
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Time to Smoke First Morning Cigarette and Lung Cancer in a Case-Control Study
We evaluated whether time to first cigarette after waking, a single-item measure of nicotine dependency, could improve stratification of lung cancer risk beyond standard smoking metrics.
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Brain Connectivity Changes over Time in Alcoholism
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Deuterium Protection of Polyunsaturated Fatty Acids against Lipid Peroxidation: A Novel Approach to Mitigating Mitochondrial Neurological Diseases
Oxidative stress is associated with numerous neurological disorders. Mitochondrial malfunction contributes to generation of reactive oxygen species (ROS) in proximity to mitochondrial membranes rich in polyunsaturated fatty acids (PUFAs). ROS…
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Heterogeneity of Alcohol Effects on Nodes of Frontocerebellar and Limbic Circuitry: Evidence from the US-France Collaborative Study
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Sample Collection in Clinical Proteomics – Proteolytic Activity Profile of Serum and Plasma
We utilized the platform to ascertain the impact of three commonly used anticoagulants (EDTA, heparin, and citrate) on the proteolytic activity profile of plasma and serum collected from a healthy…
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Permeability Enhancing Lipid-Based Co-Solvent and SEDDS Formulations of SQ641, an Antimycobacterial Agent
The objective of this study was to develop an oral preclinical liquid formulation of SQ641 and to determine the permeability across rat intestinal tissue by Ussing chamber.