Biomedical sciences publications
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Design of a Peptide Inhibitor of Tyrosine Kinase 2
The development of antisense peptide inhibitors is a relatively unexplored area of research, and here we investigate inhibitory peptides specific for the Janus-associated kinase (JAK) family member, tyrosine kinase 2 (TYK2).
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GABAB Agonism Promotes Sleep and Reduces Cataplexy in Murine Narcolepsy
We evaluated the effects of chronic administration of GHB and the GABA B agonist R -baclofen ( R -BAC) on arousal state and cataplexy in two models of narcolepsy: orexin/ataxin-3…
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The Adaptor Protein SAP Regulates Type II NKT-Cell Development, Cytokine Production, and Cytotoxicity against Lymphoma
Here, using a type II NKT-cell TCR transgenic mouse model, we demonstrated that CD1d-expressing hematopoietic cells, but not thymic epithelial cells, meditate efficient selection of type II NKT cells.
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Poor Autonomic Nervous System Functioning During Sleep in Recently Detoxified Alcohol-Dependent Men and Women
We investigated nighttime ANS functioning, and the relation between ANS activity and severity of alcohol dependence in chronic alcoholism.
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Maternal Nutrition at Conception Modulates DNA Methylation of Human Metastable Epialleles
We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. Our results demonstrate that maternal nutritional status during…
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ABT-089 and ABT-894 reduce levodopa-induced dyskinesias in a monkey model of Parkinson’s disease
Here, we examined the effect of two β2 nAChR agonists, ABT-089 and ABT-894, that previously were approved for phase 2 clinical trials for other indications.
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Comparison of the Neutral Wind Seasonal Variation from Midlatitude Conjugate Observations
The seasonal variation of F region neutral wind from the midlatitude conjugate Fabry-Perot interferometer observations has been studied.
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No Association between Germline Variation in Catechol-O-Methyltransferase and Colorectal Cancer Survival in Postmenopausal Women
Because catechol-O-methyltransferase (COMT; 22q11.21) activity is an important component of estrogen-mediated carcinogenesis, we hypothesized that germline variation in COMT may be associated with CRC survival.
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Designing Bifunctional NOP Receptor-Mu-Opioid Receptor Ligands from NOP-Receptor Selective Scaffolds. Part II
We describe a continuing structure–activity relationship (SAR) study of the NOP-selective piperidin-4-yl-1,3-dihydroindol-2-one scaffold, to obtain bifunctional activity at MOP, and a suitable ratio of NOP/MOP agonist activity that produces a…
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Sudemycin E Influences Alternative Splicing and Changes Chromatin Modifications
To determine the effect on gene expression, we performed genome-wide array analysis. Sudemycin E first causes a rapid change in alternative pre-messenger RNA splicing, which is later followed by changes…
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Hyperpolarized [1,4-C-13]-Diethylsuccinate: A Potential Dnp Substrate for in Vivo Metabolic Imaging
In this work, the applicability of a novel imaging agent, [1,4-(13)C]-diethylsuccinate, for hyperpolarized (13)C metabolic imaging of the TCA cycle was explored.
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PORTR: Pre-Operative and Post-Recurrence Brain Tumor Registration
We propose a new method for deformable registration of pre-operative and post-recurrence brain MR scans of glioma patients. To address this challenging task, our method, called PORTR, explicitly accounts for…