Biomedical sciences publications
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GABAB Agonism Promotes Sleep and Reduces Cataplexy in Murine Narcolepsy
We evaluated the effects of chronic administration of GHB and the GABA B agonist R -baclofen ( R -BAC) on arousal state and cataplexy in two models of narcolepsy: orexin/ataxin-3…
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The Adaptor Protein SAP Regulates Type II NKT-Cell Development, Cytokine Production, and Cytotoxicity against Lymphoma
Here, using a type II NKT-cell TCR transgenic mouse model, we demonstrated that CD1d-expressing hematopoietic cells, but not thymic epithelial cells, meditate efficient selection of type II NKT cells.
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Poor Autonomic Nervous System Functioning During Sleep in Recently Detoxified Alcohol-Dependent Men and Women
We investigated nighttime ANS functioning, and the relation between ANS activity and severity of alcohol dependence in chronic alcoholism.
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Conditional Ablation of Orexin/Hypocretin Neurons: A New Mouse Model for the Study of Narcolepsy and Orexin System Function
The sleep disorder narcolepsy results from loss of hypothalamic orexin/hypocretin neurons. Although narcolepsy onset is usually postpubertal, current mouse models involve loss of either orexin peptides or orexin neurons from…
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ABT-089 and ABT-894 reduce levodopa-induced dyskinesias in a monkey model of Parkinson’s disease
Here, we examined the effect of two β2 nAChR agonists, ABT-089 and ABT-894, that previously were approved for phase 2 clinical trials for other indications.
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Comparison of the Neutral Wind Seasonal Variation from Midlatitude Conjugate Observations
The seasonal variation of F region neutral wind from the midlatitude conjugate Fabry-Perot interferometer observations has been studied.
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No Association between Germline Variation in Catechol-O-Methyltransferase and Colorectal Cancer Survival in Postmenopausal Women
Because catechol-O-methyltransferase (COMT; 22q11.21) activity is an important component of estrogen-mediated carcinogenesis, we hypothesized that germline variation in COMT may be associated with CRC survival.
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Designing Bifunctional NOP Receptor-Mu-Opioid Receptor Ligands from NOP-Receptor Selective Scaffolds. Part II
We describe a continuing structure–activity relationship (SAR) study of the NOP-selective piperidin-4-yl-1,3-dihydroindol-2-one scaffold, to obtain bifunctional activity at MOP, and a suitable ratio of NOP/MOP agonist activity that produces a…
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Sudemycin E Influences Alternative Splicing and Changes Chromatin Modifications
To determine the effect on gene expression, we performed genome-wide array analysis. Sudemycin E first causes a rapid change in alternative pre-messenger RNA splicing, which is later followed by changes…
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Maternal Nutrition at Conception Modulates DNA Methylation of Human Metastable Epialleles
We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. Our results demonstrate that maternal nutritional status during…
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Type IV Collagen α1-Chain Noncollagenous Domain Blocks MMP-2 Activation Both in-Vitro and in-Vivo
In the present study, the regulation of MMP-2 activation by α1(IV)NC1 was evaluated. α1β1-integrin which is required for inhibition of angiogenesis is not playing a role in cellular invasion and inhibition of…
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mRNA Splicing-Modulatory Pharmacophores: The Total Synthesis of Herboxidiene, a Pladienolide-Herboxidiene Hybrid Analog and Related Derivatives
We report an improved enantioselective synthesis of herboxidiene and the first report of its biologically active totally synthetic analog: 6-norherboxidiene.